
Insulin Resistance May Partly Explain Higher Cardiovascular Risk After Premature Menopause - Patient Care Online
TMS 2026: In ARIC, menopause before age 40 was linked to higher CVD and CHD risk, with insulin resistance mediating about 19% of the association. Women who reached menopause before age 40 years had a higher long-term risk of cardiovascular disease (CVD) and coronary heart disease (CHD), and insulin resistance accounted for nearly one-fifth of that association. The findings come from an analysis of the Atherosclerosis Risk in Communities (ARIC) study presented at the 2026 Annual Meeting of The Menopause Society in San Diego.1,2Early menopause, occurring between ages 40 and 44 years, was not associated with increased cardiovascular risk.2Premature menopause occurs in about 1% of women. Because of estrogen deficiency and a longer postmenopausal lifespan, it has been linked to several adverse health outcomes, including CVD and osteoporosis. The cardiometabolic mechanisms behind the elevated CVD risk, however, have been unclear.1,2Zailing Xing, PhD, of the University of Vermont, and colleagues analyzed data from 4,710 postmenopausal women aged 45 to 64 years in ARIC who had no CVD at baseline.


















