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Science

Ginseng derived extracellular vesicles attenuate adipocyte hypertrophy and modulate gut microbiota and cholecystokinin responsiveness in high fat diet fed mice - Nature

We’re sharing this article early to provide faster access to peer-reviewed, accepted research. It is citable and carries a permanent DOI. This version is subject to further edits and will be replaced automatically by the final Version of Record. All legal disclaimers apply. AbstractDiet-induced obesity is associated with impaired satiety signaling and alterations in intestinal microbial communities. Plant-derived extracellular vesicles have recently emerged as bioactive dietary vesicles capable of influencing host physiology. However, the in vivo metabolic effects of Panax ginseng–derived extracellular vesicles (GDE) remain incompletely characterized. Male C57BL/6 mice were fed a low-fat diet, high-fat diet (HF), or HF supplemented with orally administered GDE (3 × 10⁹ particles, 3 times/week) for 9 weeks. Relative epididymal fat pad weight, adipose tissue histology, cholecystokinin (CCK)-mediated satiety responsiveness, gut microbiota composition, and selected intestinal inflammatory markers were evaluated. GDE administration reduced adipocyte diameter and normalized epididymal leptin mRNA expression in HF-fed mice despite comparable energy intake between HF and HF/GDE groups.

Nature·
Regional

Pope Leo tells faithful in St. Peter's Square he will gradually resume duties after cancer surgery

VATICAN CITY -- Pope Leo XIV thanked thousands of faithful in St. Peter's Square on Sunday for their prayers while he was hospitalized for an operation to remove a malignant tumor, and said he plans to gradually return to his usual duties. The crowd erupted in cheers when the pontiff showed himself in the window overlooking the square, where a week ago on the same occasion of the traditional Angelus blessing he revealed that a nodule had been located on his lung, and that it would be surgically removed.''Now that this delicate phase is behind me, I will gradually resume my activities, always with God's help and your prayers," Leo said, his voice sounding strong four days after the lower lobe of his right lung was removed. The pontiff said the experience of the last week "has made me feel especially close to those facing illness and infirmity. " He told the faithful that he had ''truly felt your support,'' and expressed ''particular gratitude to the doctors, nurses and all the staff at Gemelli hospital'' where he was treated. The pope paused for a moment and waved to the crowd before retreating into his apartment in the Apostolic Palace.

United States·ABC7 New York·
Regional

Coldest morning of the season? Temperatures plunge into the 20s and 30s

WEATHERSunday, October 18, 2026 12:45PMNEW YORK (WABC) -- Some of the coldest temperatures so far this fall greeted Tri-State residents Sunday morning, with several suburbs falling below freezing as frost developed across parts of the region. Temperatures dropped into the 20s and low 30s across portions of northwest New Jersey, the Hudson Valley and interior Connecticut. Among the coldest readings were 27 degrees in Monticello and 29 degrees in Poughkeepsie and Danbury. Morristown reached the freezing mark, while Central Park was noticeably milder at 42 degrees. The good news: the biting chill is expected to be short-lived. With clear skies and lighter winds than Saturday, temperatures are forecast to rebound into the upper 50s by the afternoon, reaching a high near 58 degrees in New York City. While milder than the morning, that's still below the seasonal average of 64 degrees. High pressure over the Northeast is keeping conditions dry and sunny Sunday, with only light northeast winds between 6 and 12 mph. The chilly pattern continues Sunday night, when temperatures will fall back into the 30s across outlying suburbs and the 40s in the city.

United States·ABC7 New York·
Automotive

11 Japanese Performance Cars That Will Make You Nostalgic For The '90s

Few things evoke '90s nostalgia in a gearhead as much as a Japanese performance car. Call it a biased enthusiast view, but really, the roster of icons that Japan churned out during this decade was just absurd: the MkIV Toyota Supra, Nissan Skyline GT-R, Honda NSX, and Mazda RX-7. And that's before we mention the all-wheel-drive (AWD) rally homologation specials, front-wheel-drive hot hatches, mid-engine fun machines, and other iconic rear-wheel-drive sports cars. The fact is, those four heavy hitters still hog the spotlight today. Yes, for people who lived in the 1990s, they don't just evoke nostalgia; it's like they never left the 1990s. But instead of allowing these four cars to steal all the thunder, for this piece, we're focusing on all the other Japanese performance cars that remain undisputed '90s royalty even if they don't dominate the algorithms today. Cars that showcased Japanese factory engineering and won over fans worldwide — even those who only experienced them via a dual-shock controller in "Gran Turismo. " We are talking legends like the Toyota Celica GT-Four, Nissan Silvia S14, and Mitsubishi Lancer Evo V. Feeling nostalgic yet? We're just getting warmed up.

Jalopnik·
Science

World’s longest cross-sea high-speed rail bridge sees closure of first navigation channel span - Global Times

The southern navigation channel bridge of the Hangzhou Bay Cross-Sea Railway Bridge achieves closure on October 17, 2026. Photo: Screenshot from People's DailyAs the steel truss girder of the southern navigation channel bridge of the Hangzhou Bay Cross-Sea Railway Bridge saw closure on Saturday evening, it became the first of the three navigation channel bridges to reach this milestone, marking a landmark breakthrough in the construction of the world's longest cross-sea high-speed railway bridge. This achievement has laid a solid foundation for subsequent stay-cable tensioning, bridge deck construction, and the full structural system conversion of the entire bridge. The bridge forms a crucial section of the Nantong-Ningbo High Speed Railway. At 29.2 kilometers, it is currently the world's longest and highest-standard clustered cross-sea railway bridge under construction, according to the People's Daily. The project consists of northern, central, and southern navigation channel bridges, as well as mid-sea approach bridges and shoal-area approach bridges. The southern navigation channel bridge that has just been closed is situated in the central waters of Hangzhou Bay.

Global Times·
Arts & Culture

Ariadne/Dido and Aeneas review – English Touring Opera conjures two strikingly different mythological worlds

English Touring Opera’s autumn season has a mythological theme – which, in practice, means operas about women getting left behind. Touring alongside Gluck’s Orpheus and Eurydice is this compact double bill, pairing Dido and Aeneas with Elena Langer’s Ariadne, a 20-minute scene for soprano setting words by Glyn Maxwell, which was premiered by Almeida Opera in 2002. Langer’s mini-opera is essentially a monologue, sung persuasively here by Jessica Cale, her powerful soprano diamond-bright. Anna Morrissey’s production, though, has six people on stage: abandonment feels like something active as well as passive. It begins with Theseus leaving, disentangling himself from both the sleeping Ariadne and the red thread that links them, spooling from a heap on the floor – it’s as if he got back from the labyrinth the night before. When Ariadne wakes he’s still there, pacing in the shadows or turning her bed on its rotating platform. Catwalk Coraline … Lydia Shariff and Isabelle Atkinson with members of the ensemble in Dido and Aeneas. Photograph: Richard Hubert SmithLanger writes, captivatingly, for four instruments: oboe, violin, viola and cello, playing without a conductor.

The Guardian Culture·
Science

Astronomers spot a black hole tearing apart a star 3,500 light-years off-center - Interesting Engineering

Can a dying star reveal the location of a black hole that has otherwise gone unnoticed? Turns out, it can. Astronomers have now traced a stellar destruction event to a massive black hole about 3,500 light-years from the center of its host galaxy. This discovery offers a rare look at a so-called wandering black hole and raises a further question: how did it end up so far from home?

Interesting Engineering·
Science

China’s space rice experiment could help astronauts grow their own food - Interesting Engineering

Chinese astronauts aboard the Tiangong space station have completed what they called the “Autumn harvest” of their in-space rice cultivation experiment. According to reports, the astronauts successfully collected, sowed, and stored a new batch of rice on the space station. Reported on October 18, this marks a major milestone in the project’s hopes to reproduce rice over successive generations entirely in space.

Interesting Engineering·
Sports

Big 12 admits error in Notre Dame-BYU, says Irish had time for one more play - TSN

PROVO, Utah -- The Big 12 says one second should have been placed back on the clock at the end of Saturday night's Notre Dame-BYU game, which would have given the Fighting Irish one final play to win. Big 12 officials ruled the game had ended after Notre Dame quarterback CJ Carr threw incomplete to Jaden Greathouse in the end zone, giving No. 8 BYU a 28-24 victory. But replays showed the ball hit the ground with one second remaining, which would have given No. 2 Notre Dame another play on second down. "Following the Big 12's review of the final play of Saturday's Notre Dame-BYU game, it was determined that time remained on the clock when the ball hit the ground and the play was incorrectly cleared by the replay officiating crew," the Big 12 said in a statement. "The Conference will conduct a complete review of its end-of-game officiating process in advance of next week's games. "Since Notre Dame is an FBS independent, its games are officiated by the leagues of its opponent. Fighting Irish coach Marcus Freeman appeared to take issue with a non-pass interference call against BYU cornerback Evan Johnson but was not asked about a clock issue, describing the final play as "chaos.

TSN·
Sports

Eugenio Chacarra notches third win in 2026, Rory McIlroy struggles in final round at DP World India Championship - PGA Tour

12H AGO3 Min ReadEugenio Lopez-Chacarra nearly drains 51-yard shot, sets up birdie on No. 12 at Genesis Scottish OpenPlayers in This ArticleFavorite players to keep them at the top of your leaderboard and get the latest updates. or Sign Up to save favorites across devices. Written by Associated PressNEW DELHI (AP) — Eugenio Chacarra won the DP World India Championship by two strokes on Sunday to maintain a late-season surge that has lifted the Spanish golfer atop the Race to Dubai standings on the DP World Tour. After a third-place finish at the FedEx Open de France and then a second place at last week's Open de España presented by Madrid, Chacarra got his third win of the season by completing a 9-under 63 early Sunday and then shooting 70 to finish at 21-under par for the week at Delhi Golf Club. Chacarra jumped ahead of Patrick Reed into first place in the season-long Race to Dubai that will culminate next month and crown the DP World Tour's top player of the year. Chacarra is in better form than both the American and Rory McIlroy, the other realistic contender for the title.

PGA Tour·

Large fire breaks out after deadly incident at Canadian military base, officials say - CBS News

Canada's defense minister said Saturday that people were killed and injured in an incident at a military base in Alberta that caused a major fire. It was not immediately clear how many people were killed or injured, but a doctor at a hospital in the city of Edmonton, 120 miles northwest, told Canada's national broadcaster that patients were being brought to hospitals across the city as health care facilities around the base became "completely overwhelmed" by the number of people needing care. "This number of patients would overwhelm the city of Edmonton," Dr. Warren Thirsk, an emergency department physician at the Royal Alexandra Hospital, told CBC News. "It is more patients than any of us want to count right now. It's a disaster. It's a one in every 15 to 25-year disaster. ""I'm saddened to share that there have been both fatalities and injuries as a result of an incident on the base," Defense Minister David McGuinty said. Emergency crews and military personnel gather at the Wainwright Health Centre as injured military members are treated after a fire at Canadian Forces Base Wainwright, outside of Wainwright, Alberta, on Saturday, Oct. 17, 2026.

CBS News·

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