Red Heat Health Alert announced - Bedford Borough Council

New studies of trends in the global burden of measles and pertussis offer a reminder of how much vaccination has achieved and a warning of the need to build more resilient and sustainable vaccination programs. This is a preview of subscription content, access via your institution

Chronic airway infection and inflammation form a destructive partnership in cystic fibrosis. Recent evidence shows that Pseudomonas aeruginosa persistent infections can redirect immunity towards tissue injury. Access Nature and 54 other Nature Portfolio journals

IntroductionHigh-grade serous tubo-ovarian carcinoma (HGSOC) is a highly aggressive malignancy with a paucity of available biomarkers for therapeutic intervention. HGSOC exhibiting homologous recombination deficiency (HRD) demonstrates marked sensitivity to targeted treatments such as platinum-based chemotherapy and Poly ADP-Ribose polymerase (PARP) inhibitors1,2,3. Specifically, PARP inhibitors demonstrate synthetic lethality in HRD-positive cancers by inhibiting the repair of damaged DNA, significantly extending progression-free survival and improving long-term outcomes in patients with HRD-positive ovarian cancer4,5,6. Given the significant relationship between HRD status and patient treatment outcomes, the identification of HRD is crucial for precision therapy. Existing HRD tests analyze both mutations in DNA repair genes, such as BRCA1/2, and genomic instability.

We’re sharing this article early to provide faster access to peer-reviewed, accepted research. It is citable and carries a permanent DOI. This version is subject to further edits and will be replaced automatically by the final Version of Record. All legal disclaimers apply. AbstractMonascin (MS) and ankaflavin (AK) are bioactive yellow pigments produced by Monascus species, known for their health benefits and safety profile compared to monacolin K. This study developed an integrated strategy combining Response Surface Methodology (RSM) for submerged fermentation optimization and a downstream purification process to maximize MS and AK production by Monascus purpureus TST. Although the results of this study demonstrate that RSM did not successfully predict the optimal production conditions, the RSM optimization revealed significant interactions between sucrose, ammonium sulfate, and magnesium sulfate heptahydrate. Verification experiments confirmed that the optimal culture conditions for M. purpureus TST were 200 g/L sucrose, 17.5 g/L (NH4)2SO4, and 0.1 g/L MgSO4·7H2O.

How quickly your heart rate returns to normal after exercise can reveal a surprising amount about your underlying health. If your heart hammers in your chest when you walk up the stairs, or you need to gasp for air while jogging to catch a bus, it may be a sign that you are not in peak physical shape. Yet what happens after you stop exercising can be just as revealing about the inner workings of your body. Enter the heart rate recovery (HRR) test. This is the difference between your pulse when your heart is pumping hard during exercise, and how fast it beats about a minute after you have finished. But your HRR is also so much more than that. A poor result can act as an early warning sign, helping to uncover hidden problems with the rest of the body. Crucially, that includes your overall risk of death. Back in 1999, scientists from the Cleveland Clinic, Ohio, published some striking results. They had tested the HRRs of 2,400 adults, then followed them for six years. The team found that people with low heart rate recovery were around four times more likely to die during the study period.

The rise of dementia burden in the Middle East and North Africa (MENA) region poses challenges to the scientific community, as this heterogeneous region is marked by political instability and conflict. This commentary questions the exclusion of Israel from dementia research in the MENA region in previous research and proposes an inclusive approach guided by scientific rigor and available evidence, rather than political views. These efforts are critical to dismantle scientific bias and ensure socially responsible and comprehensive dementia research to advance diagnosis and treatment not only in MENA region but in diverse populations. IntroductionThere is a recent scientific effort to draw attention to the rapid aging and rise of dementia prevalence in the Middle East and North Africa (MENA) region, resulting from challenges in dementia diagnosis, burden, and care in the MENA countries1,2. For example, a comprehensive review synthesized evidence across epidemiological, socioeconomic, environmental, and policy dimensions, with recommendations for the region1.