Frozen in action: Visualizing how a cancer drug scaffold is built - Phys.org
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The bacterial enzyme SacC builds the five-ring core shared by safracin B and the anticancer drug ecteinascidin 743 (trabectedin), forming two new carbon-to-carbon bonds through a seven-step catalytic cascade. Above, the enzyme is seen by cryo-electron microscopy, with its working parts in different colors. Credit: Haraguchi et al., 2026
A joint research group led by Ryo Tanifuji and Hiroki Oguri from the University of Tokyo and Yoshikazu Tanaka from Tohoku University has visualized SacC, an enzyme that plays a key role in building the complex five-ring core of safracin B. This core structure is shared with trabectedin, a drug used to treat soft tissue sarcoma.
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