“Empathy Sharpened by Analysis” — Journalist and Mental Health Advocate Mark Henick, BA’10, on STU Liberal Arts - STU.CA

Held-out test subset of \(\mathscr {D}\) \(\textbf{e}_{l_t} \in \mathbb {R}^{8}\)

We’re sharing this article early to provide faster access to peer-reviewed, accepted research. It is citable and carries a permanent DOI. This version is subject to further edits and will be replaced automatically by the final Version of Record. All legal disclaimers apply. AbstractAbnormal phosphate concentrations are common in sepsis, but the prognostic relevance of serum phosphate and the association between recorded intravenous phosphate exposure and mortality remain uncertain. This retrospective cohort study used MIMIC-III, MIMIC-IV, and a single-center database from the First Affiliated Hospital of Chongqing Medical University. Adults with ICD-coded sepsis, a first ICU admission, and an ICU stay longer than 24 h were included. Admission phosphate was evaluated with restricted cubic spline regression for 28- and 90-day mortality. Recorded intravenous phosphate exposure was assessed using multivariable logistic regression in the 48- and 72-h landmark populations. Propensity-score matching and inverse-probability-of-treatment weighting were performed at both landmarks. A target-trial emulation was also performed. Cohorts 1 and 2 included 15,426 and 967 patients, respectively.

We’re sharing this article early to provide faster access to peer-reviewed, accepted research. It is citable and carries a permanent DOI. This version is subject to further edits and will be replaced automatically by the final Version of Record. All legal disclaimers apply. AbstractTo systematically compare unilateral anterior crossbite (UAC) and monosodium iodoacetate (MIA) models for temporomandibular joint osteoarthritis (TMJOA) research. This study used healthy adult male SPF-grade Sprague–Dawley (SD) rats, aged 6–8 weeks and weighing 180–200 g, with a total of 24 rats. After a 7-day acclimatization period, the rats were randomly and equally allocated into three groups: a normal control group (NC), an occlusion intervention group (UAC), and a drug injection group (MIA). Condylar height at the anterior, central, and posterior regions was quantitatively measured via a computer-aided image analysis system to elucidate the observed morphological alterations. Pathological assessments of the TMJ were conducted using Safranin O-Fast Green staining, hematoxylin and eosin (HE) staining, and immunohistochemistry (IHC).