Japan to drop term ‘abnormal delivery’ to ease emotional burden on parents - The Japan Times

Background: Abnormal uterine bleeding (AUB) is a common gynaecological complaint, and thyroid dysfunction may contribute to menstrual abnormalities. This study evaluated the prevalence of thyroid dysfunction among women presenting with AUB and its association with clinical characteristics. Methods: This observational study was conducted in the Department of Obstetrics and Gynaecology, Kempegowda Institute of Medical Sciences, Bengaluru, India, from January 2020 to June 2021. It included 100 women with AUB. Demographic and clinical data, such as age, parity, body mass index (BMI), type and duration of AUB, thyroid status, family history, and goitre and thyroid-related symptoms, were documented. Thyroid function tests were used to group the participants into the following categories: euthyroid, subclinical, hypothyroid, and hyperthyroid. Results: The mean age was 34.85 ± 8.29 years, and the mean BMI was 24.74 ± 3.36 kg/m². Thyroid dysfunction was found to be present in 20% of the participants. Heavy menstrual bleeding was the most common AUB pattern (40%), which was not significantly associated with thyroid status (p = 0.398). Significant associations were observed between thyroid st

Credit: FatCamera / Getty Images Children who develop cancer produce an unusually high number of antibodies that attack DNA repair machinery, new research suggests. The findings, published in Frontiers in Immunology, could help lead to early screening that prevents cancer from developing later on, during adolescence. The pathogenic, penetrating autoantibodies, which can cross over into cells, predominantly targeted six proteins involved in DNA repair. They may represent a previously unrecognized mechanism through which people are predisposed to cancer at a young age.

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We’re sharing this article early to provide faster access to peer-reviewed, accepted research. It is citable and carries a permanent DOI. This version is subject to further edits and will be replaced automatically by the final Version of Record. All legal disclaimers apply. AbstractAbnormal phosphate concentrations are common in sepsis, but the prognostic relevance of serum phosphate and the association between recorded intravenous phosphate exposure and mortality remain uncertain. This retrospective cohort study used MIMIC-III, MIMIC-IV, and a single-center database from the First Affiliated Hospital of Chongqing Medical University. Adults with ICD-coded sepsis, a first ICU admission, and an ICU stay longer than 24 h were included. Admission phosphate was evaluated with restricted cubic spline regression for 28- and 90-day mortality. Recorded intravenous phosphate exposure was assessed using multivariable logistic regression in the 48- and 72-h landmark populations. Propensity-score matching and inverse-probability-of-treatment weighting were performed at both landmarks. A target-trial emulation was also performed. Cohorts 1 and 2 included 15,426 and 967 patients, respectively.

We’re sharing this article early to provide faster access to peer-reviewed, accepted research. It is citable and carries a permanent DOI. This version is subject to further edits and will be replaced automatically by the final Version of Record. All legal disclaimers apply. AbstractTo systematically compare unilateral anterior crossbite (UAC) and monosodium iodoacetate (MIA) models for temporomandibular joint osteoarthritis (TMJOA) research. This study used healthy adult male SPF-grade Sprague–Dawley (SD) rats, aged 6–8 weeks and weighing 180–200 g, with a total of 24 rats. After a 7-day acclimatization period, the rats were randomly and equally allocated into three groups: a normal control group (NC), an occlusion intervention group (UAC), and a drug injection group (MIA). Condylar height at the anterior, central, and posterior regions was quantitatively measured via a computer-aided image analysis system to elucidate the observed morphological alterations. Pathological assessments of the TMJ were conducted using Safranin O-Fast Green staining, hematoxylin and eosin (HE) staining, and immunohistochemistry (IHC).