Near-infrared-responsive thia-hexaphyrin-based covalent organic frameworks for cancer phototherapy - Nature
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AbstractCovalent organic frameworks (COF) have emerged as promising phototherapeutic platforms for tumor therapy, where the columnar π-arrayed metal-free photosensitizers serve as both a cooperative light-harvesting antenna and a semiconducting scaffold for efficient charge-carrier separation and transport. However, the phototherapeutic agents based on COFs are usually activated with ultraviolet and visible light, resulting in the limitation of deep-tissue phototherapy. Herein, we develop near-infrared-responsive COFs through elaborate design and synthesis of a thia-hexaphyrin building block, which feature well-aligned conjugation skeletons for the generation of reactive oxygen species (ROS) and photothermal effect upon 808 nm laser irradiation, outperforming conventional porphyrin-based COFs.
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