Mechanical resonator–based quantum computing - Science | AAAS

We’re sharing this article early to provide faster access to peer-reviewed, accepted research. It is citable and carries a permanent DOI. This version is subject to further edits and will be replaced automatically by the final Version of Record. All legal disclaimers apply. AbstractHow macrophages fine-tune their appetite to fulfil their clearance role is incompletely understood. Phagocytosis exacerbates cytoplasmic crowding, but whether macrophages can sense this increase and use it to regulate their phagocytic capacity has never been investigated. Here, we test the hypothesis that phagosomes exert a strain on the nucleus, which in turn responds to the intracellular mechanical inputs influencing macrophage appetite. Combining genetic manipulation and live in vivo imaging, we show that engulfed apoptotic bodies indent and deform the nucleus of Drosophila embryonic macrophages, and that phagocytosis increases Lamin B levels. Importantly, we show that silencing Lamin B or components of the LINC complex negatively regulates apoptotic body engulfment in vivo.

Gomez's Hamburger System. This artist's impression of the Gomez's Hamburger system shows the stacked layers of gas and dust as they rotate around a young star. ALMA observations reveal a direct view of its vertical structure at millimeter wavelengths, allowing astronomers to map the location of the millimeter-sized dust grains and several different gas-phase molecules, which have arranged themselves into distinct levels. Credit: NSF/AUI/NSF NRAO/P. Vosteen. Astronomers using the Atacama Large Millimeter/submillimeter Array (ALMA) were surprised to discover the earliest phases of giant planet formation between the dense layers of gas and dust in the "Gomez's Hamburger" system, referred to as GoHam.