Blood pressure drug losartan boosts metabolism by stimulating brown fat - News-Medical

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AbstractBackground & AimsElevated antimicrobial antibodies have been reported up to 6 years before diagnosis of Crohn’s disease (CD), but the specific antibody response is unclear. Here, we characterized the antimicrobial antibody responses before CD diagnosis in healthy first-degree relatives (FDRs) of patients with CD. MethodsThe CCC-GEM (Crohn’s and Colitis Canada – Genetic, Environmental, Microbial) Project nested case-control cohort consisted of FDRs who later developed CD (n = 77), matched 1:4 by age, sex, follow-up duration, and geographical location with healthy FDRs (n = 304). Sera at enrollment were probed for antimicrobial reactivity using a microbiota antigen microarray and a flagellin peptide cytometric bead array. Conditional logistic regression was used to assess association with CD onset, and partial Spearman was used to correlate serologic responses with lactulose-to-mannitol ratio (LMR), C-reactive protein (CRP), and fecal calprotectin (FCP). False discovery rate was controlled using the Benjamini-Hochberg method (q < 0.05).

The rapid-access cancer care program Same Day/Next Day (SDND) served a higher proportion of patients with high socioeconomic risk for poor outcomes than the traditional health care path, and more socially vulnerable patients initiated therapy, according to results presented at the 19th AACR Conference on The Science of Cancer Health Disparities, held Oct. 18–21 in Atlanta. "Delay in care is one of the largest negative predictors of cancer outcomes," said Joseph P. Flemming, D. O., from Jefferson Abington Hospital, who presented the study. "The SDND program rapidly connects patients with expert guidance to support them in navigating the beginning of their cancer journey. "

Cognition often deteriorates when the brain's main blood vessels are clogged, but a Columbia-led study published in JAMA shows that cognition cannot be improved by opening the blockages with stenting or surgery. "We had hoped that improving blood flow in the brain in this way would improve cognition—and there were tantalizing clues from animal studies and case series that it would," says study leader Randolph Marshall, M. D., the Elisabeth K. Harris Professor of Neurology at Columbia University Vagelos College of Physicians and Surgeons.

Thyroid storm and diabetic ketoacidosis (DKA) are life-threatening endocrine emergencies that rarely occur concurrently. Their coexistence presents significant diagnostic and management challenges, particularly when associated with new-onset autoimmune diabetes. We report the case of a 26-year-old female with untreated hyperthyroidism who presented with altered mental status, severe tachycardia, dehydration, and generalized weakness. Laboratory evaluation demonstrated thyroid storm with undetectable thyroid-stimulating hormone (TSH) and markedly elevated thyroid hormone levels. Concurrent findings were consistent with severe DKA, including hyperglycemia (828 mg/dL), high anion gap metabolic acidosis, ketonemia, and ketonuria. Hemoglobin A1c was elevated to 9.5% from 5.4% less than three months earlier, suggesting rapid progression to insulin deficiency. Low C-peptide levels of 0.4 further support evolving autoimmune diabetes. The patient additionally demonstrated severe hyperosmolar hypernatremia, acute kidney injury, supraventricular tachycardia, and elevated cardiac biomarkers likely secondary to metabolic stress. She was treated in the intensive care unit (ICU) with aggressive i