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‘How do we welcome the stranger, with humanity or anger?’ The forgotten Germans who found refuge in Ireland

In the early 18th century, a few thousand Germans fled religious persecution and near starvation in their homeland and ended up in remote rural Irish villages. The Irish Palatines, as they were known, were poor, conservative homesteaders who couldn’t speak the language and were the object of suspicion and violence – precursors to the displaced Syrians or Afghans of the past decade. Their story is told in Refuge, a co-production between Staatstheater Mainz and the Irish company Fishamble. Part love story, part social commentary, it is performed by a mixed cast, mainly in English but with some German interludes. It focuses on a German couple, Hannah and Peter, who have lost one of their two sons through illness and are trying to make a go of it on farmland on the edge of a small town in Limerick. Their Protestantism and their reluctance to mix with the Irish add to a sense of peril. Peter is driven by another motive. He owes his plot of land to the manor’s (invisible) English squire, Thomas Southwell. The 1st Baron Southwell of Castle Matrix is keen to dilute the locals’ Catholicism and so provides the Germans with cheap rent in return for their obedience.

The Guardian Culture·
Health

Next-generation total-body PET scanner can produce diagnostic-quality images in as little as 1 minute - Medical Xpress

A next-generation total-body PET/CT scanner can produce diagnostic-quality images in as little as 1 minute of scanning, according to research presented today at the 39th Annual Congress of the European Association of Nuclear Medicine (EANM'26). Even its fastest images were rated more highly on average than those from a standard PET/CT scanner. PET/CT is widely used to diagnose, stage and monitor cancer. Conventional PET/CT scanners have a short axial field of view, meaning they image the body section by section, typically requiring five to six 'bed positions' to cover the body from head to thigh. Long-axial field-of-view (LA-FOV) systems capture a much larger part of the body at once and detect more of the signal emitted by the radiotracer, raising the possibility of much shorter scans without sacrificing image quality.

Medical Xpress·
Gaming

Slim Or Fuller? Atelier Karia "Body Shape Change Feature" Confirmed

"What kind of Karia would you like to adventure with? " The Koei Tecmo fantasy alchemy RPG Atelier Karia: The Night Kingdom & the Guide of Memories is making its way to the Switch 2 early next year. In an update from Gust this week, it confirmed a "body shape change feature" is officially on the way.

Nintendo Life·
Health

TRIM2 negatively regulates antiviral immunity by degradation of MDA5 and STAT2 during influenza A virus infection - Nature

We’re sharing this article early to provide faster access to peer-reviewed, accepted research. It is citable and carries a permanent DOI. This version is subject to further edits and will be replaced automatically by the final Version of Record. All legal disclaimers apply. AbstractThis study identifies TRIM2 as an interferon-stimulated gene (ISG) regulated by both type I and type II interferons. Contrary to the typical antiviral role of most ISGs, TRIM2 significantly enhances influenza A virus (IAV) replication both in vitro and in vivo. Mechanistically, TRIM2 functions as a negative regulator of the MDA5-mediated antiviral signaling pathway, contributing to the suppression of IFN-β production in part through promoting K48-linked polyubiquitination of MDA5. It directly interacts with MDA5 via its CC and Fn domains, promoting K48-linked polyubiquitination of MDA5 at Lysine 538, which leads to its proteasomal degradation and subsequent suppression of IFN-β production. Furthermore, TRIM2 interacts with and degrades STAT2 via K48-linked ubiquitination, further suppressing interferon signaling.

Nature·
Nation

Burnaby Election results: Next mayor must oversee city's fast-growing future - Vancouver Sun

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Vancouver Sun·
Health

Equatorial Guinea is expanding an ambitious malaria elimination plan - Yahoo News Canada

MALABO, Equatorial Guinea (AP) — With its torrential rains, tropical forests and omnipresent humidity, Equatorial Guinea provides the perfect conditions for mosquitoes to breed. For centuries, mosquito-borne diseases, in particular malaria, have dictated the fate of residents of this central African nation, impacting how they lived, worked and died. But Bioko island, off mainland Equatorial Guinea, has managed to sharply reduce malaria infections and deaths. Bioko, roughly half the size of Rhode Island, has used familiar tools: indoor spraying, mosquito nets and keeping control of the larvae population. Its success, however, has depended on something less easily replicated: two decades of painstaking data collection, sustained funding and workers going door to door to win residents' trust. Now the tiny, oil-rich country wants to bring that approach to its mainland and eliminate malaria altogether. But the expansion of Bioko's strategy presents formidable challenges, from porous international borders to the sheer scale of the territory.

Yahoo News Canada·
Sports

Ramblings: Raining Hats in Florida, Jankowski Goal Streak, Greaves Shutout, Cagnoni Scratched (Oct 18) - DobberHockey

The defending Stanley Cup champion Carolina Hurricanes are as deep as any team in the NHL. Yet it is still a surprise to see Mark Jankowski on a six-game goal-scoring streak. Jankowski scored a power-play goal in the Hurricanes' 3-2 win over Winnipeg on Saturday. Jankowski also took a season-high four shots while also winning 10 faceoffs. Jankowski is a secondary option for the Canes both at even strength and the power play, while he is shooting at an unsustainable 40%. The 32-year-old Jankowski is only worth adding in the absolute deepest of leagues, but credit where it is due on the recent goal scoring. Nikolaj Ehlers' first goal of the season came against his former team. Ehlers is averaging under two shots per game and is shooting at under 6%, which explains the lack of goals to start the season.

DobberHockey·
Health

Northampton hospital recognised for tiny pacemaker work - BBC

6 hours agoAlex PopeNGHThe leadless pacemaker - which is the metallic-looking object shown on this model - has been fitted into about 300 patients by the trustA hospital that has implanted tiny pacemakers for 10 years has been recognised as a "centre of excellence". Northampton General Hospital said the honour, bestowed by the manufacturer, was for the way "it has pioneered" the fitting of the leadless pacemaker and for training other teams around the UK. The device is 93% smaller than traditional pacemakers, weighs about two grams and can be inserted in about 20 minutes. It is so small that it cannot be felt under the surface of the skin, the trust explained. The device, made by global US healthcare company Medtronic, has been used in Northampton since 2016 and in 2024 it became the first hospital trust in the UK to use the latest form. The trust has fitted it in about 300 patients so far. NGHStaff Northampton General Hospital were treated with a cake to mark the achievementDr David Sharman, a consultant cardiologist who implanted the hospital's first device, said his team had been training specialist nurses, cardiac physiologists and radiographers from across England.

BBC·
Health

Hospital recognised for tiny pacemaker work - Yahoo

A hospital that has implanted tiny pacemakers for 10 years has been recognised as a "centre of excellence". Northampton General Hospital said the honour, bestowed by the manufacturer, was for the way "it has pioneered" the fitting of the leadless pacemaker and for training other teams around the UK. The device is 93% smaller than traditional pacemakers, weighs about two grams and can be inserted in about 20 minutes. It is so small that it cannot be felt under the surface of the skin, the trust explained. The device, made by global US healthcare company Medtronic, has been used in Northampton since 2016 and in 2024 it became the first hospital trust in the UK to use the latest form. The trust has fitted it in about 300 patients so far. Staff Northampton General Hospital were treated with a cake to mark the achievement [NGH]Dr David Sharman, a consultant cardiologist who implanted the hospital's first device, said his team had been training specialist nurses, cardiac physiologists and radiographers from across England. "This kind of pacemaker is the future for pacemakers," he said. Do you have a story suggestion for Northamptonshire? Contact us below.

Yahoo·
Entertainment

'The Queen told us off for riding tricycles indoors' - BBC

'The Queen told us off for riding tricycles indoors'7 hours agoNeve Gordon-FarleighJonathan Birch/BBCLady Glenconner said it was a "privilege" spending her childhood at Holkham Hall in NorfolkOne of Princess Margaret's former ladies in waiting recalls being told off by a nine-year-old Queen Elizabeth II for riding a tricycle indoors at her Norfolk stately home. Lady Glenconner, who has known the Royal Family all her life, said it was a privilege growing up at Holkham Hall, which is her family's ancestral estate. Now aged 94, she remembers riding tricycles as a young child with the Queen's younger sister, Princess Margaret - and being chided by the future monarch. "We weren't meant to be there at all, going round and round, and down the steps of the Marble Hall came the Queen... she looked at us and she said 'Margaret, Anne, very very naughty, what are you doing'? " said Lady Glenconner. "Princess Margaret and I whirled round the hall one more time and we shot off on our tricycles screaming with laughter," she added.

BBC·
Technology

$SanDisk (SNDK.US)$ We'll likely test back MA200 (1200) again when Korean Market opens tomorrow...It's looking messy right now with oil again expected to surge... - Moomoo

Featured Tech Stocks represent leading technology companies with strong market presence, influential in their industries, and notable for robust innovation and profitability. These firms are market leaders, significantly affecting the tech sector and broader economy. Featured Tech Stocks represent leading technology companies with strong market presence, influential in their industries, and notable for robust innovation and profitability. These firms are market leaders, significantly affecting the tech sector and broader economy.

Moomoo·
Entertainment

Southend MP vows to help teenager access life-changing drug - BBC

13 hours agoDebbie Tubby,at Parliament SquareandLewis Adams, EssexShaun Whitmore/BBCBrogan Johnson (centre) dropped an open letter off at 10 Downing Street with her sister and mother on TuesdayAn MP has vowed to help a 17-year-old who is fighting for a life-changing drug to be made available on the NHS. Brogan Johnson, from Leigh-on-Sea, Essex, cannot afford the medication that would slow her Friedrich's ataxia condition, which affects her heart, nervous system and mobility and is life-limiting. The drug, omaveloxolone, has been approved for private use in the UK, but costs about £1,000 a day. David Burton-Sampson, Labour MP for Southend West and Leigh, said it was a "really tragic" situation. Friedrich's ataxia is a progressive neurodegenerative disease that affects about 1,100 people in the UK and gives them an average life expectancy of 35-50 years. Omaveloxolone, which is branded as Skyclarys, was approved as a treatment for the condition in April 2025. However, discussions between pharmaceutical company Biogen and the National Institute for Health and Social Care (NICE) to get it on the NHS have stalled.

BBC·
Entertainment

Today's NYT Connections Hints (and Answer) for Sunday, October 18, 2026 - Lifehacker

If you’re looking for the Connections answer for Sunday, October 18, 2026, read on—I’ll share some clues, tips, and strategies, and finally the solutions to all four categories. Along the way, I’ll explain the meanings of the trickier words and we’ll learn how everything fits together. Beware, there are spoilers below for October 18, NYT Connections #1,225! Read on if you want some hints (and then the answer) to today’s Connections game. If you want an easy way to come back to our Connections hints every day, bookmark this page. (If you play Wordle or Strands, check out our hints for those games, too.) Below, I’ll give you some oblique hints at today’s Connections answers. And farther down the page, I’ll reveal the themes and the answers. Scroll slowly and take just the hints you need! The category types in today’s Connections puzzleHere are spoiler-free hints that describe the type of each category in today’s Connections:Yellow category - Related nouns. Green category - Related nouns. Blue category - Related nouns. Purple category - Wordplay.

Lifehacker·
Health

From bias to signal: the prognostic meaning of baseline pharmacotherapy in clinical high-risk for psychosis - Nature

We’re sharing this article early to provide faster access to peer-reviewed, accepted research. It is citable and carries a permanent DOI. This version is subject to further edits and will be replaced automatically by the final Version of Record. All legal disclaimers apply. Observational evidence is increasingly central to prognostic precision in early intervention in mental health, particularly in Clinical High-Risk for Psychosis (CHR-P) populations where trajectories are heterogeneous and clinical decisions unfold sequentially. In this context, baseline pharmacological exposure should not be treated merely as a nuisance variable or dismissed because it may reflect confounding by indication, confounding by severity, or protopathic bias. These mechanisms limit causal interpretation, but they may also explain why treatment exposure carries prognostic information. Antipsychotic, antidepressant, benzodiazepine, or combined exposure at CHR-P inception may encode prior clinical deterioration, symptom burden, comorbidity, treatment-seeking pathways, clinician concern, partial treatment response, or pharmacologically attenuated expression of emerging psychosis.

Nature·
Regional

Save-On-Foods loyalty program members had personal information accessed in cybersecurity breach

British ColumbiaA major Canadian supermarket chain has notified customers in its loyalty program that their personal information was accessed during a cybersecurity breach. The chain says it discovered the activity on one of its servers, which was "quickly contained" before launching an investigation. Names were accessed, possibly contact information and addresses, but no number on how many affectedArden McLeod · CBC News · Posted: Oct 18, 2026 1:21 AM EDT | Last Updated: 3 minutes agoListen to this articleEstimated 3 minutesThe audio version of this article is generated by AI-based technology. Mispronunciations can occur. We are working with our partners to continually review and improve the results. Save-On-Foods requires online shoppers to have a More Rewards profile, on top of anyone hoping to receive in-store discounts. (Ben Nelms/CBC)A major Canadian supermarket chain has notified customers in its loyalty program that their personal information was accessed during a cybersecurity breach. The Western Canadian grocery chain Save-On-Foods says it discovered unauthorized activity on one of its servers on Oct.

Canada·CBC·