The fascinating tale of a heart that died twice: best podcasts of the week - The Guardian

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Combination strategies enable simultaneous activation and silencing of key target genes to correct molecular pathways in pancreatic cancer. For the first time, scientists have designed combination therapies of small nucleic acid therapeutics based on the specific molecular characteristics of a tumor. These novel therapies work in an opposite but complementary way to regulate gene expression. This innovative approach, tested in pre-clinical models of pancreatic ductal adenocarcinoma (PDAC), shows superior anti-cancer effects compared to single nucleic acid therapies, offering the potential of flexible, precise, and personalized cancer treatments.

Executive SummaryOn October 15, 2026, unauthorized access to application identities within the ConnectWise Cloud Backup (formerly SkyKick Cloud Backup) environment enabled attackers to compromise at least 162 Microsoft 365 tenants. The breach was executed via a supply-chain attack, leveraging a stolen application credential to authenticate as a trusted service principal in customer environments. This allowed the attacker to inherit all permissions previously granted to the application, including broad access to emails, files, and directory data. The attack was confirmed by multiple independent sources, including Microsoft, Huntress, and ConnectWise. The incident led to the suspension of ConnectWise Cloud Backup and related services, with ongoing investigations and remediation efforts. There is currently no evidence that backup archives were accessed or exfiltrated, but the full scope of tenant impact remains under review. The attack bypassed multi-factor authentication (MFA) due to its use of application credentials rather than user logins.