Old Blood Cells Have Been Transformed Into Brain Stem Cells That Get Younger As They Age - ScienceAlert
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Aging is the price paid for the ability of experiencing existence, one might philosophize. Natural cellular aging begins with differentiation. Once a stem cell becomes a specific cell type, it's locked in forever: fat cells can never become muscle cells, no matter how hard one wishes, or pokes and prods at them in front of the mirror. Or so it goes in nature, but scientists can definitely transform cells, as if biologically compensating for all the failed alchemical attempts of the past. Now, scientists have transformed old blood cells into young brain stem cells, which continued to grow younger as they grew older. The researchers, from the University Hospital of Bonn and the University of Bonn, in Germany, described their methods in the journal Aging Cell. Cellular transformations can be done in two main ways. The first, more circuitous route turns a specific cell back into a pluripotent stem cell, or an embryonic "blank slate," and then into a different cell type. The second method involves a "direct conversion," which skips the middle stage and directly transforms a cell into a different type.
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