NSW Health Pathology uses Power Apps to scale genomics and unify quality management - Microsoft

Chronic airway infection and inflammation form a destructive partnership in cystic fibrosis. Recent evidence shows that Pseudomonas aeruginosa persistent infections can redirect immunity towards tissue injury. Access Nature and 54 other Nature Portfolio journals

A Saskatchewan milestone: Students will begin studies in the first-ever Master of Occupational Therapy and Master of Speech-Language Pathology programs at the University of Saskatchewan. (Photo: David Stobbe for the University of Saskatchewan) The Government of Saskatchewan is recognizing a milestone in the expansion of health professional training in the province. Students will begin studies in the first-ever Master of Occupational Therapy and Master of Speech-Language Pathology programs at the University of Saskatchewan (USask).

New studies of trends in the global burden of measles and pertussis offer a reminder of how much vaccination has achieved and a warning of the need to build more resilient and sustainable vaccination programs. This is a preview of subscription content, access via your institution

We’re sharing this article early to provide faster access to peer-reviewed, accepted research. It is citable and carries a permanent DOI. This version is subject to further edits and will be replaced automatically by the final Version of Record. All legal disclaimers apply. AbstractMonascin (MS) and ankaflavin (AK) are bioactive yellow pigments produced by Monascus species, known for their health benefits and safety profile compared to monacolin K. This study developed an integrated strategy combining Response Surface Methodology (RSM) for submerged fermentation optimization and a downstream purification process to maximize MS and AK production by Monascus purpureus TST. Although the results of this study demonstrate that RSM did not successfully predict the optimal production conditions, the RSM optimization revealed significant interactions between sucrose, ammonium sulfate, and magnesium sulfate heptahydrate. Verification experiments confirmed that the optimal culture conditions for M. purpureus TST were 200 g/L sucrose, 17.5 g/L (NH4)2SO4, and 0.1 g/L MgSO4·7H2O.

IntroductionHigh-grade serous tubo-ovarian carcinoma (HGSOC) is a highly aggressive malignancy with a paucity of available biomarkers for therapeutic intervention. HGSOC exhibiting homologous recombination deficiency (HRD) demonstrates marked sensitivity to targeted treatments such as platinum-based chemotherapy and Poly ADP-Ribose polymerase (PARP) inhibitors1,2,3. Specifically, PARP inhibitors demonstrate synthetic lethality in HRD-positive cancers by inhibiting the repair of damaged DNA, significantly extending progression-free survival and improving long-term outcomes in patients with HRD-positive ovarian cancer4,5,6. Given the significant relationship between HRD status and patient treatment outcomes, the identification of HRD is crucial for precision therapy. Existing HRD tests analyze both mutations in DNA repair genes, such as BRCA1/2, and genomic instability.