New study identifies protein factor linked to chronic liver disease - News-Medical
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The mechanisms that cause the world's most common chronic liver disease - Metabolic dysfunction-associated steatotic liver disease (MASLD) - to develop and progress are not still fully understood. Now, a study by the University of Barcelona has identified a new factor involved in the development of the disease: the protein ENT1, which allows the transport of small molecules essential for the functioning of liver cells into the cell. The results of the study, carried out with patients and animal models, open the door to exploring future therapies.
The research, published in the journal Metabolism, is led by Professor Sandra Pérez-Torras, member of the Department of Biochemistry and Molecular Biomedicine at the UB's Faculty of Biology, the Institute of Biomedicine of the University of Barcelona (IBUB) and the Sant Joan de Déu Research Institute (IRSJD). The study also involved significant contributions from Professor Marçal Pastor-Anglada (UB, IBUB and IRSJD); postdoctoral researcher Aida Mata-Ventosa (UB, IBUB and IRSJD), one of the paper's co-first authors; and researcher Maria Isabel Hernández-Alvarez (UB and IBUB).
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