“Frontal Slow-Wave Asymmetry in Obstructive Sleep Apnea and Its Modulation During CPAP Titration” - Oxford Academic

We’re sharing this article early to provide faster access to peer-reviewed, accepted research. It is citable and carries a permanent DOI. This version is subject to further edits and will be replaced automatically by the final Version of Record. All legal disclaimers apply. AbstractEpithelial-to-mesenchymal transition (EMT) is a key driver of colorectal cancer (CRC) progression and metastasis. Identifying pivotal EMT-related genes and novel therapeutic approaches may enhance patient outcomes. In this study, we analyzed EMT-related gene expression in CRC using TCGA data and identified differentially expressed genes via protein-protein interaction networks and centrality analysis. The anticancer effects of ZnO and ZnO@glu-Carvacrol nanoparticle were evaluated in HCT-116 and HT-29 cells using MTT assays, gene expression profiling of proliferation and apoptosis markers, colony formation, and scratch wound-healing assays. Among 200 EMT-related genes, 75 were upregulated and 69 downregulated in CRC. Seventeen hub genes were identified, with SERPINE1 and BGN showing the strongest association with poor patient survival in exploratory survival analyses.

IntroductionClinical trial evidenceFDA approval and regulatory developmentsCardiometabolic and secondary benefitsFuture directionsReferences What can treatments targeting weight and metabolism offer people with obstructive sleep apnea, and which questions must clinical trials still answer?

A small genetic difference can turn a snail into the mirror image of another. Now, researchers studying Japanese land snails have identified a gene that helps determine whether their shells coil clockwise or counterclockwise, offering new clues into how animals develop their left and right sides. The study, led by researchers at the University of Nottingham and Tohoku University in Japan, examined wild Euhadra snails to understand the biological mechanisms behind this phenomenon, known as chirality. Their findings suggest that subtle variations in a gene responsible for producing a protein called myosin can result in healthy snails with opposite body plans.