Endometriosis Guidelines Differ on Biomarkers and Repeat Surgery - The American Journal of Managed Care
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A review of 47 endometriosis guidelines found most came from high-income settings and diverged on biomarkers, repeat surgery, and fertility referral. Most of the 47 endometriosis guidelines reviewed worldwide came from high-income settings, and they disagreed on biomarkers, repeat surgery, and fertility referral, according to a scoping review published October 14, 2026, in Communications Medicine.1Endometriosis affects about 10% of people of female sex of reproductive age, or roughly 190 million worldwide.2 Diagnostic delays of 12 years or more have been reported, although some high-income settings have reduced that to about 6 years, according to the authors.1 They noted that no globally applicable care guidance exists. Guidelines Concentrate in High-Income RegionsThe research team searched PubMed, Embase, and Scopus through October 2025 and grey literature through March 2026. They included 47 guidelines, 28 in English and 19 in other languages. Thirty-eight were national guidelines, and 9 were international or regional. Europe produced about a third of all 47, while Africa accounted for 2% and the Eastern Mediterranean for 4%.
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