During a heat event - Fraser Health

We’re sharing this article early to provide faster access to peer-reviewed, accepted research. It is citable and carries a permanent DOI. This version is subject to further edits and will be replaced automatically by the final Version of Record. All legal disclaimers apply. AbstractWaterlogged archeological wood (WAW) undergoes lignin oxidation in the presence of air, generating quinones and other conjugated chromophores that cause severe discoloration. As conventional reductants (e.g., Na2S2O4 and NaBH4) struggle to balance between decolorization performance and operational compatibility, a thiourea dioxide (TDO)–amine borane (AB) composite formulation was developed for WAW decolorization. A paper-based solid-phase model with a covalently linked o-quinone motif was constructed for quantitative evaluation. The performances of TDO, dimethylamine borane (DMAB), tert-butylamine borane (TBAB), and their combinations were evaluated on both model and WAW samples. The TDO–AB formulations outperformed single-component treatments in decolorization effect and rate.

Findings may help identify patients who are less likely to respond to neoadjuvant therapy, potentially informing timely consideration of alternative treatment strategies or surgery 68Ga-HER2 PET/CT images before neoadjuvant therapy, at end of second cycle, and before surgery. (A) Baseline scan demonstrated soft-tissue lesion measuring approximately 2.3 × 2.2 cm in upper outer quadrant of left breast, with marked radiotracer uptake and SUVmax of 10.1. (B) At end of second cycle, imaging revealed residual lesion of approximately 2.2 × 1.0 cm in same region, without abnormal radiotracer accumulation. (C) Preoperative imaging demonstrated further reduction in lesion size to approximately 2.0 × 0.6 cm, with no abnormal tracer uptake detected. Image source: adapted from: Gao S, Zhang Z, Cheng C et al, Journal of Nuclear Medicine 2026 (CC BY 4.0)

ORCID: orcid.org/0000-0002-3666-39521, Yuki Hyodo1, Ichiro Kurakazu1, Taisuke Uchida1, Ryota Hirose1, Masanari Kuwahara1, Takumi Kita1, Koki Kato1, Li Ziyang1, Gai Eto1 & … Yasuharu Nakashima1 We’re sharing this article early to provide faster access to peer-reviewed, accepted research. It is citable and carries a permanent DOI. This version is subject to further edits and will be replaced automatically by the final Version of Record. All legal disclaimers apply.

Grieving family welcome PM's brain cancer promise2 hours agoHannah WalshSouth of England Clare and Mark GrimleySeren was only four years old when she died due to a brain tumourA family whose daughter died from a brain tumour have welcomed Prime Minister Andy Burnham's promises for more investment into brain cancer research. Clare and Mark Grimley, from Bournemouth, Dorset, lost their four-year-old daughter Seren to a brain cancer, called an ependymoma, a year after she was diagnosed. Seren had brain surgery, learnt to walk again, went through proton beam therapy (PBT) and had a "really positive" end of treatment scan, before the tumour grew back within months. The promises from Burnham, including a review of brain cancer progress, come after a meeting with Archie Goodburn, a commonwealth swimmer who has three inoperable brain tumours. The family described Seren as a "very girly girl" who "loved her princesses, loved her unicorns". She first started to display symptoms such as a headache, being lethargic and losing her balance in July 2025 and died a year later.

Site search2 hours agoIsaac AsheDerbyBBCHannah Simpson will likely one day have to undergo life-saving surgeryHannah Simpson has been told by doctors that she has an "up to 100% chance" of developing hereditary cancer. The 32-year-old lost her mum Jeanette Simpson to the disease in 2022, and her late granddad Terry Cook also had hereditary cancer. She said: "It's hard enough losing somebody, but then to have lost that person to something that was caused by the same mutation that you carry, it kind of hits you again. "Trying to make light of her situation, Hannah now jokes each year with her consultant that it might be time to have "that chat" with a surgeon, and undergo life-altering surgery to save her life. SuppliedHannah, right, carries the same gene mutation that caused the cancer which killed her mum JeanetteHer family carries a mutation in the APC gene, which causes familial adenomatous polyposis (FAP), a condition affecting about one in 8,000 to 10,000 people in the UK. "In basic terms I am at an extremely high risk," Hannah said.