Curbing the neutrophil surge: new treatment offers hope for autoimmune diseases - Asia Research News |

Gaku Yamamoto1,2, Mahiru Kawano1, Mina Sakata1, Michiko Bun1,3, Aasa Shimizu1, Erika Nakatsuka1, Yasuto Kinose1,2, Shuang Zhang4, Ryota Nakashima4, Kenjiro Sawada1,5 & … Michiko Kodama1 We’re sharing this article early to provide faster access to peer-reviewed, accepted research. It is citable and carries a permanent DOI. This version is subject to further edits and will be replaced automatically by the final Version of Record. All legal disclaimers apply.

Latent autoimmune diabetes in adults (LADA) may resemble type 2 diabetes mellitus (T2DM), creating diagnostic uncertainty and delaying appropriate treatment. This case illustrates the recognition of adult-onset autoimmune diabetes in an older, lean physician and the challenges surrounding the acceptance of insulin therapy. A 63-year-old male physician presented with an eight-week history of polyuria, polydipsia, nocturia, fatigue, reduced exercise tolerance and unintentional weight loss from approximately 62 kg to 53 kg. His body mass index had historically ranged from 19 to 22 kg/m², with no recognised features of metabolic syndrome. His brother reportedly had LADA. Initial investigations demonstrated a random plasma glucose of approximately 30 mmol/L and glycated haemoglobin (HbA1c) of 12.1% (108 mmol/mol). Glutamic acid decarboxylase antibodies were strongly positive (>110 U/mL), whereas islet antigen-2 antibodies were negative. Serum bicarbonate was normal, and renal function was preserved. C-peptide was not measured. Insulin was recommended at diagnosis because of severe symptomatic hyperglycaemia and marked catabolic weight loss. The patient initially declined injectable ther

Thyroid storm and diabetic ketoacidosis (DKA) are life-threatening endocrine emergencies that rarely occur concurrently. Their coexistence presents significant diagnostic and management challenges, particularly when associated with new-onset autoimmune diabetes. We report the case of a 26-year-old female with untreated hyperthyroidism who presented with altered mental status, severe tachycardia, dehydration, and generalized weakness. Laboratory evaluation demonstrated thyroid storm with undetectable thyroid-stimulating hormone (TSH) and markedly elevated thyroid hormone levels. Concurrent findings were consistent with severe DKA, including hyperglycemia (828 mg/dL), high anion gap metabolic acidosis, ketonemia, and ketonuria. Hemoglobin A1c was elevated to 9.5% from 5.4% less than three months earlier, suggesting rapid progression to insulin deficiency. Low C-peptide levels of 0.4 further support evolving autoimmune diabetes. The patient additionally demonstrated severe hyperosmolar hypernatremia, acute kidney injury, supraventricular tachycardia, and elevated cardiac biomarkers likely secondary to metabolic stress. She was treated in the intensive care unit (ICU) with aggressive i

Thyroid storm and diabetic ketoacidosis (DKA) are life-threatening endocrine emergencies that rarely occur concurrently. Their coexistence presents significant diagnostic and management challenges, particularly when associated with new-onset autoimmune diabetes. We report the case of a 26-year-old female with untreated hyperthyroidism who presented with altered mental status, severe tachycardia, dehydration, and generalized weakness. Laboratory evaluation demonstrated thyroid storm with undetectable thyroid-stimulating hormone (TSH) and markedly elevated thyroid hormone levels. Concurrent findings were consistent with severe DKA, including hyperglycemia (828 mg/dL), high anion gap metabolic acidosis, ketonemia, and ketonuria. Hemoglobin A1c was elevated to 9.5% from 5.4% less than three months earlier, suggesting rapid progression to insulin deficiency. Low C-peptide levels of 0.4 further support evolving autoimmune diabetes. The patient additionally demonstrated severe hyperosmolar hypernatremia, acute kidney injury, supraventricular tachycardia, and elevated cardiac biomarkers likely secondary to metabolic stress. She was treated in the intensive care unit (ICU) with aggressive i