“Beyond Detecting Cancer Recurrence: Can Whole-Genome Sequencing-Based ctDNA Monitoring Help Personalize Adjuvant Treatment?
An exciting new study published in The Oncologist highlights the clinical potential of Signatera Genome, a whole-genome sequencing (WGS)-based, tumor-informed circulating tumor DNA (ctDNA) assay, not only for detecting molecular residual disease (MRD), but also for potentially informing adjuvant treatment decisions.
British ColumbiaPolice have arrested one woman and are searching for two more suspects after three separate unprovoked stranger attacks happened in Vancouver on Thursday. Separate, unprovoked attacks happened in different areas of city on ThursdayMichelle Gomez · CBC News · Posted: Oct 17, 2026 2:24 PM EDT | Last Updated: October 17Listen to this articleEstimated 3 minutesThe audio version of this article is generated by AI-based technology. Mispronunciations can occur. We are working with our partners to continually review and improve the results. Screengrabs from video shared by the police show the suspect in Thursday's second stranger attack, left, which happened in East Vancouver; and augmented footage of the suspect in the third incident, right, which took place downtown around 6 p.m. PT. (Vancouver Police Department)Police in Vancouver have arrested one woman and are still searching for two other suspects after three separate stranger attacks happened in different areas of the city on Thursday. "In all three of these incidents the victims did nothing wrong," said Const. Megan Lui with the Vancouver Police Department (VPD). The first attack happened shortly after 6 a.m.
Milky Way’s first microblazar candidate sits 12,000 light-years away, offering a rare ground-level lab for studying relativistic jetsA black hole 12,000 light-years away is firing a jet of plasma almost directly toward Earth. At that distance, no known or expected danger to Earth has been identified by the researchers or the institutions involved. What astronomers have actually found is rarer and more interesting than a threat. Researchers have identified IRAS 18293-0941 as a compelling candidate for the Milky Way’s first microblazar, a class of object that gives astrophysicists a close-up laboratory for studying some of the most violent physics in the galaxy. What Astronomers FoundThe discovery centers on a binary system whose black hole expels plasma jets at close to three-quarters the speed of light, pointed almost directly toward Earth. The system pairs a hot, massive star with a black hole that completes a full orbit roughly every 11.38 days. Material drawn from the companion star feeds the black hole, and some of that matter gets expelled outward as opposing jets traveling at approximately three-quarters the speed of light. Terminology matters here.
Published: October 17, 2026 at 2:22p.m. EDTThe Detroit Red Wings have placed defenceman Jacob Bernard-Docker on waivers, according to Postmedia’s Bruce Garrioch. The 26-year-old battled an upper-body injury and was activated from injured reserve last week. He has yet to play a game at the NHL level this season. Bernard-Docker had one goal and five points in 63 games with Detroit last season while averaging 14:49 of ice time per game. A native of Banff, Alta., Bernard-Docker was selected No. 26 overall in the 2018 NHL Draft by the Ottawa Senators. He spent parts of five seasons in the nation’s capital before joining the Buffalo Sabres via trade in March of 2025. Bernard-Docker then signed as a free agent with the Red Wings later that summer. He is currently on a two-year deal that runs through 2027-28 and pays him $1.6 million annually. He has seven goals and 29 points in 207 career NHL regular season games spread out over six seasons.
A habitable earth-sized world orbiting a free floating Gas giant -- Grok via Astrobiology.com
[Max Planck Institute for Extraterrestrial Physics] Liquid water is considered essential for life. Surprisingly, however, stable conditions that are conducive to life could exist far from any sun.
Eugénie Lacroix, a Quebec woman diagnosed with breast cancer at 46 years old, is urging the province to expand access to earlier screening as advocates call for changes to a program that currently targets women aged 50 to 74.
Now living with stage 4 breast cancer, Lacroix hopes sharing her experience will push Quebec’s next government to act on recommendations to extend organized screening to younger women.
Fraction of planetesimal interactions that resulted in a capture (left) or a temporary capture (right) for planetesimals of different sizes (R) and stars with different separations. Each point represents anywhere from 10,000-100,000 simulations. The single case results were also obtained with REBOUND using the same set-up for direct comparison. The grey dotted line represents the theoretical amount of captures for the single case derived by Grishin et al. (2019). -- [astro-ph. EP]
[astro-ph. EP] Planet formation requires growth over 12 orders of magnitude in size, from micron-sized dust grains to fully formed planets.
Forests that stood on Mozambique's coast thousands of years ago now lie beneath shallow seas, and they have become fish-filled "peat reefs" with marine life comparable to coral reefs, researchers report in Scientific Reports. A team from the Bazaruto Center for Scientific Studies (BCSS) Ocean Observatory, led by Mario Lebrato, documented the submerged peat in the Bazaruto Archipelago in the Western Indian Ocean. BCSS, founded in 2017, describes itself as Africa's first permanent ocean observatory. Working with universities and institutions in the U. K., U. S. and Canada, the team believes it has carried out the first ecological study of peat reefs anywhere in the tropics. Old forests, new seafloorRadiocarbon dating shows the peat formed between about 300 and 5,000 years ago, and chemical analysis indicates it came mostly from coastal land plants and trees. Some samples contain up to 40% organic carbon by dry weight. Lebrato said the coastline has very little natural hard seabed, mostly shifting sand. As rising seas expose the old peat layers, they create rare solid habitat where marine life can settle, hide and feed.
The Red Wings have been carrying nine defensemen through the early going this season, something that’s largely unsustainable. They’ve taken a step toward reducing that surplus as Sportsnet’s Elliotte Friedman reports (Twitter link) that blueliner Jacob Bernard-Docker has been placed on waivers.
The 26-year-old joined Detroit in the 2025 offseason, inking a one-year, $875K contract in the hopes that a fresh start could eventually give him a more permanent place in the lineup. Last year, that was largely the case. Bernard-Docker played in 63 games (compared to just 40 the year before between two different teams) and while he only put up five points offensively, he logged nearly 15 minutes per game of ice time while chipping in with 87 blocked shots and 66 hits. That performance was good enough for the Red Wings to sign him to a new two-year, $3.2MM deal back in March.
Published: October 17, 2026 at 2:05p.m. EDTAn Ontario career college has suspended its academic operations as a result of a province-wide pause on student financial assistance to all private post-secondary institutions. Trillium College, with campuses in St. Catharines, Kingston, Oshawa, Sudbury and Cobourg, paused classroom and online instruction as of Friday, it said in a notice to students obtained and confirmed by The Canadian Press. It comes after Colleges and Universities Minister Nolan Quinn announced earlier this month that Ontario Student Assistance Program payments to career colleges and other private post-secondary institutions are paused while an audit is underway. Trillum wrote that it is offering interest-free payment arrangements, but many students have said they cannot make those payments without OSAP funding. “Many students have also asked for more time to assess their financial circumstances, explore alternative payment options and determine how they can realistically continue their education,” the college wrote. “Continuing normal classroom operations without a viable funding solution would place the orderly completion of student programs at greater risk.
AbstractBackgroundMultiple sclerosis (MS) is characterized by immune dysregulation, yet the molecular alterations present at disease onset remain incompletely understood. We sought to characterize immune cell-specific proteomic changes before treatment initiation in early MS and assess their impact on immune cell communication. MethodsWe performed high-resolution proteomic profiling of four major peripheral immune cell populations, CD4+ and CD8+ T cells, CD19+ B cells, and CD14+ monocytes, from newly diagnosed, treatment-naïve individuals with MS and matched healthy controls. Differential protein expression, pathway enrichment, genetic overlap, and ligand–receptor analyses were performed. ResultsAll four immune cell populations exhibit distinct proteomic alterations that discriminate individuals with MS from healthy controls. Differentially expressed proteins are enriched in pathways related to coagulation, antigen processing, vesicle trafficking, oxidative phosphorylation, and cellular stress responses. Disease-associated proteins overlap with established MS susceptibility genes, with the strongest enrichments observed in CD14⁺ monocytes and CD19⁺ B cells.
File photoAs Albertans head to the polls for the final day of voting in Alberta’s referendum on Monday, residents of Lloydminster are grappling with a question most Canadians never have to consider: what happens to a city when the province it’s half built in decides to leave the country? Read more: Sask. building permits jump 32.5 per cent, builders eye regionLloydminster is split almost evenly down the middle by the Alberta-Saskatchewan border, with roughly 32,000 people living under one municipal government but two provincial governments. The city’s RCMP detachment sits on the Alberta side. Its only hospital sits on the Saskatchewan side. Schools teach the Saskatchewan curriculum citywide, and the whole arrangement runs on a charter signed by both provinces. That charter, not a federal treaty, is what makes the Border City work. Former Lloydminster mayor Jeff Mulligan, who was in office when the charter was last updated in 2013, says it was never built to survive one of its two partners leaving Canada. “That charter is signed on by two provinces, not a province and a separate country,” Mulligan told CTV News.
Previews indicate Nintendo really cares about this one
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Chaz Horton was a big deal in Edmonton in 1979. So big a deal that the sports reporter was cryogenically frozen until he was needed most. With the Oilers in “show me” mode with McDavid, that time is now. Hey Oilers fans, I was looking forward to the road trip to California. I mean, everyone knows the Golden State is 30 per cent sunshine, 28 per cent seafood buffets, 13 per cent Disney, 10 per cent hidden taxes, and 95 per cent California girls. I hoped the state hadn’t changed much since 1979. The media are travelling with the team most of the trip, so that should be wild. Since I was going away for several days, I got a dog sitter for Sue. My mailman, Max, said he’d keep an eye on my trailer. The gang at DFO Edmonton is getting used to having me around, and this trip will be a good bonding opportunity. I mean, it’s not every day your colleague is a 92-year-old from the past. Technically, I’m 92, but in reality I’m only 45 years old, and most people say my emotional capacity is at a 12-year-old’s level. That’s a compliment, right?
13 hours agoLynette HorsburghNorth WestNewsham Scream ParkNewsham Scream Park is located at the former Grade II listed Newsham Park HospitalWarning: This article includes references to extreme sexual activities which some readers may find upsetting. A woman said she was shocked and disgusted by what she described as a "depraved" adults-only section of a family Halloween attraction. Robyn Doughty said she expected "fun scares" at Newsham Scream Park in Liverpool but the optional Hellfire Club experience included obscene sexual language and physical elements for which there had been no adequate warning. The attraction said the over-18s section "centred around a sinister secret society" and visitors had to sign a waiver outlining "the nature of the experience" before entering. Doughty said the attraction should "explicitly warn people" about what she described as a "sickening" experience that "doesn't belong at a family park". In a statement, the scream park said its "terms and conditions, which must be agreed to before entering the attraction, outline the nature of the experience, including its adult and horror themes, physical interaction and sensory effects".
