Witcher 3 Switch 2 patch rolls out today with a number of changes, including alterations to resolution and "visual clarity"

IntroductionProstate cancer is the most common malignancy in men that accounts for 10% of male cancer-related deaths and is expected to increase in incidence in the coming decades1. Its clinical trajectory is highly variable, with disease courses ranging from localised disease with long indolent phases that often require no therapy, to early-onset cancer that typically necessitates definitive treatment with curative intent2 and life-threatening metastatic prostate cancer3. The management of newly diagnosed prostate cancer is primarily based on established clinical and pathological information along with small gene or mRNA panels. The most pressing unmet clinical needs include reliable prognostic approaches to minimize overtreatment and the identification of therapeutic targets4. This is especially challenging due to the considerable molecular heterogeneity of the disease. Its genomic landscape is dominated by structural variation (SV) and copy-number alteration (CNA) drivers, while in contrast, drivers involving small mutations including single-nucleotide variants (SNVs) and insertions-deletions (indels) are relatively infrequent5,6.

Dumpster Gang, a cooperative sandbox game with mischievous raccoons for up to four players. will …

Hello all! Welcome to another wonderful week of PC games, and mounting bloodlust. As I type these words, a neighbour has started using a leafblower. I hate leafblowers. They are mutant hairdryers from Hell. They scatter my thoughts like the tiny, tiny quantity of leaves in the neighbour's garden – a quantity of leaves you could very easily sweep up by hand in two minutes, if you had even the slightest bit of gumption. What's that? You think I should release vipers into the neighbour's toolshed? What a capital idea! But sadly I don't have any vipers to hand, and besides, I have to finish writing this list of new PC games. There are exactly as many games in the list as there are leaves in the neighbour's garden. He'll be at it for hours, no doubt. Please read, while I order in some fresh vipers.

Cyberpunk Edgerunners’ second season is out tomorrow, and while I didn’t love the 10-episode story, I’m always down to return to Night City. There are so many familiar sights, and sometimes familiar faces, to see every time we go back. This time, you might recognize one face from not only Cyberpunk 2077, but also from belonging to one of the biggest names in the video game industry. Hideo Kojima, the director of the Metal Gear series, Death Stranding, and the upcoming, Xbox-led Physint, makes a brief appearance in Cyberpunk 2077 as Hideyoshi Oshima, a braindance producer who is visiting Night City during the events of the “Heist” quest. You can find him talking to other hotel guests as you scope out the area while on a job. The character has Kojima’s likeness, so if you know of the guy, it’s easy to spot him. Fast forward six years, and Hideyoshi appears once more in Edgerunners II. I was surprised when I saw him, and then just as the review embargo dropped early this morning, CD Projekt Red confirmed that yep, Kojima did return for the cameo. Spotting a familiar face, chooms? 👀 You may remember seeing him in Konpeki Plaza during The Heist in 2077.