Thymic health and immunotherapy outcomes in patients with cancer - Nature

Could the foods teenagers eat and the drinks they choose offer clues to their mental health? Researchers followed thousands of Australian students over three years to investigate the connection. Study: Longitudinal associations between dietary intake and common mental disorders among adolescents in Australia. Image Credit: Pixel-Shot / Shutterstock

48 minutes agoEmily HoltMonica ThomasMonica is the founder of charity Women's Health Hope This report contains detailed descriptions of medical symptoms. Monica Thomas was in her teens when she started experiencing intimate itching and soreness, but despite numerous trips to the doctors it was dismissed as thrush. Her symptoms got worse, with sores and blisters leaving her in constant pain. "I was bed bound for quite a long time because I couldn't walk," she says. Monica says she was examined 28 times in six months before being offered a biopsy. She says "we don't really talk about" gynaecological health as a society so there is a taboo around speaking about symptoms. "Even when we go to the doctors, for me, the embarrassment of having to get undressed...with these doctors looking it is embarrassing," she says. "But equally when you're in pain or it's itching and you've got discomfort, living with it is just as bad. "The 34-year-old from Suffolk was eventually diagnosed with a condition called lichen sclerosus.

Latent autoimmune diabetes in adults (LADA) may resemble type 2 diabetes mellitus (T2DM), creating diagnostic uncertainty and delaying appropriate treatment. This case illustrates the recognition of adult-onset autoimmune diabetes in an older, lean physician and the challenges surrounding the acceptance of insulin therapy. A 63-year-old male physician presented with an eight-week history of polyuria, polydipsia, nocturia, fatigue, reduced exercise tolerance and unintentional weight loss from approximately 62 kg to 53 kg. His body mass index had historically ranged from 19 to 22 kg/m², with no recognised features of metabolic syndrome. His brother reportedly had LADA. Initial investigations demonstrated a random plasma glucose of approximately 30 mmol/L and glycated haemoglobin (HbA1c) of 12.1% (108 mmol/mol). Glutamic acid decarboxylase antibodies were strongly positive (>110 U/mL), whereas islet antigen-2 antibodies were negative. Serum bicarbonate was normal, and renal function was preserved. C-peptide was not measured. Insulin was recommended at diagnosis because of severe symptomatic hyperglycaemia and marked catabolic weight loss. The patient initially declined injectable ther