The 2026 Europe report of the Lancet Countdown on health and climate change: narrowing window for decisive health action - The Lancet

From Libby Sallnow and Richard Smith, Co-chairs of the Lancet Commission on the Value of Death, London, UK

Humans could become extinct by the year 2100 due to malicious use of AI or nuclear conflict, according to a new global risk assessment. They top a list of 17 major threats to human health over the next 75 years, which also includes cuts to aid spending by wealthy countries, the climate crisis and childhood malnutrition. The experts behind The Lancet Commission on 21st Century Global Threats to Health said all the threats interact, meaning they must be addressed together – but stressed that there was “a realistic route to act” on each. “Decisions made by leaders today will shape the health and wellbeing of the next generation,” said Prof Christopher Murray, commission co-chair and the director of the Institute for Health Metrics and Evaluation, University of Washington. To create its list, the commission modelled how many years in good health might be lost due to sickness, disability or early deaths due to each threat, based on current trajectories – a measure known as disability-adjusted life years (Dalys).

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IntroductionDepression and anxiety outcomesEffects on reward-related and behavioral disordersWhy study findings differEffects in severe mental illnessSafety concerns and adverse psychiatric signalsLimitations of current evidenceReferences Medicines that change appetite also influence brain circuits that govern emotion and reward, raising questions about their role in psychiatric care.

IntroductionPathophysiology of PCOS and reproductive dysfunctionMechanistic rationale for GLP-1 in fertility improvementEffects on metabolic and hormonal parametersEvidence on fertility and pregnancy outcomesPreclinical and translational evidenceSafety and pregnancy considerationsLimitations and research gapsReferences Weight, insulin, and ovarian hormones connect PCOS with infertility, raising questions about where GLP-1 therapies could fit in reproductive care.