Self-organizing “pencil beam” laser could help scientists design brain-targeted therapies - MIT News

Phyllodes tumors of the breast are rare fibroepithelial neoplasms characterized by significant heterogeneity regarding morphology, biological behavior, and clinical outcome. This review summarizes current developments in the diagnosis, histopathological and molecular classification, therapeutic management, and emerging technologies associated with phyllodes tumors of the breast. A literature search was conducted across PubMed/MEDLINE, Scopus, Embase, and Google Scholar, focusing on publications from the 2000-2026 period. The literature search covered publications from January 1, 2000, to September 30, 2026, and was last updated on September 30, 2026. Mammography, ultrasound, and magnetic resonance imaging contribute to preoperative assessment, although significant diagnostic overlap with fibroadenomas persists. Core needle biopsy is a key diagnostic tool, yet lesion heterogeneity can limit the accuracy of histological classification. Advances in molecular pathology have identified mutations and pathways associated with the progression and aggressiveness of phyllodes tumors, though these have not yet replaced morphological assessment. Surgical excision with negative margins remains

Phyllodes tumors of the breast are rare fibroepithelial neoplasms characterized by significant heterogeneity regarding morphology, biological behavior, and clinical outcome. This review summarizes current developments in the diagnosis, histopathological and molecular classification, therapeutic management, and emerging technologies associated with phyllodes tumors of the breast. A literature search was conducted across PubMed/MEDLINE, Scopus, Embase, and Google Scholar, focusing on publications from the 2000-2026 period. The literature search covered publications from January 1, 2000, to September 30, 2026, and was last updated on September 30, 2026. Mammography, ultrasound, and magnetic resonance imaging contribute to preoperative assessment, although significant diagnostic overlap with fibroadenomas persists. Core needle biopsy is a key diagnostic tool, yet lesion heterogeneity can limit the accuracy of histological classification. Advances in molecular pathology have identified mutations and pathways associated with the progression and aggressiveness of phyllodes tumors, though these have not yet replaced morphological assessment. Surgical excision with negative margins remains

You may have heard that the pen is mightier than the sword, but did you know that the pencil is mightier than the 7th Panzer Division? Here is Battleplan to educate us on the subject. In this WW2 real-time strategy game, you issue orders by drawing on a big pseudo-paper map based on geographical survey data. Then you sit back and watch as thousands of troops, tanks, planes and artillery wotsits strive to transform your arbitrary doodles into actual conquered territory. While you don't control units directly in Battleplan, the devs say there's a lot of nuance to the pencilling. It's not just writing "PLS BOMB XOXOXOX" over the nearest enemy supply dump: you can try your hand at curving breakthrough attacks, planned withdrawals, preparatory bombing runs, reconnaissance, counterattacks, and other such majestic strategickal balderdash.

How to keep mice out of your home before the first cold nightWhen temperatures drop in fall and winter, mice might seek your home for food and shelter. And it only takes a quarter-inch gap — about the diameter of a pencil — or a hole as small as a dime for them to squeeze through and make it inside. Here’s your guide on how to protect your home from any uninvited mouse friends. Where they get inThere are many small, hidden places mice can use to get inside your home.