Safety and effectiveness of ten common in-vitro fertilisation add-ons: a systematic review and meta-analysis - The Lancet

Smoking during pregnancy is associated with adverse maternal, fetal, and neonatal outcomes. Although behavioral counseling remains first-line treatment, pharmacotherapy may be considered when counseling alone is insufficient. This scoping review mapped the available evidence on the safety and effectiveness of bupropion for smoking cessation during pregnancy. The review was conducted according to Joanna Briggs Institute methodology and reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR). MEDLINE (PubMed), Embase, the Cochrane Library, PsycINFO, and ClinicalTrials.gov were searched without date restrictions for English-language studies evaluating bupropion for smoking cessation during pregnancy. Two reviewers independently screened records, and the review team extracted data on smoking cessation, maternal safety, and fetal or neonatal outcomes. Of 599 records identified, 13 sources of evidence met the inclusion criteria. Maternal and fetal safety findings were generally reassuring, with no consistent increase in maternal adverse events, major congenital malformations, preterm birth, impaired fet

In pooled phase 3 data, mepolizumab lowered mean yearly systemic corticosteroid exposure by 178.97 mg in patients with a BEC of ≥150 cells/µL. Mepolizumab (Nucala) reduced total yearly systemic corticosteroid (SCS) exposure, particularly high-dose courses, in patients with COPD and type 2 inflammation receiving inhaled triple therapy, according to pooled phase 3 data presented at the American College of Chest Physicians (CHEST) 2026 Annual Meeting in Phoenix.¹,²Although treatment guidelines recommend SCS for COPD exacerbations, these agents are associated with complications in this population, prompting interest in targeted therapies capable of limiting their use.¹ Mepolizumab, a humanized monoclonal antibody targeting interleukin-5 (IL-5), is approved for patients with COPD and an eosinophilic phenotype.

Losing your train of thought or searching for a familiar word can raise some serious concerns for women approaching menopause. Researchers at Toronto Metropolitan University are working on investigating how this transition affects memory and how these changes impact brain health later in life. On this Menopause Day, Natasha Rajah, a professor of Psychology and Tier 1 Canada Research Chair in Sex, Gender and Diversity in Brain Health, Memory and Aging at TMU, is highlighting the research examining menopause and memory related issues showing signs of early dementia.

We present a case of a six-month-old female with a five-month history of right-sided torticollis that showed little improvement despite physical therapy. She presented to the emergency department due to parental concern for pneumonia, with congestion and cough without respiratory distress. Physical examination demonstrated leftward rotation and right lateral flexion of the head and cervical spine, consistent with the previously diagnosed right-sided torticollis. Chest radiographs were obtained in the workup for pneumonia and incidentally revealed segmentation anomalies of the cervical and upper thoracic spine as well as multiple bilateral bifid and fused ribs, more pronounced on the right. The radiographic findings were interpreted as highly suggestive of Klippel-Feil syndrome (KFS). In the setting of refractory torticollis and characteristic congenital vertebral abnormalities, the diagnosis of KFS was made. No acute complication requiring immediate intervention was documented. Referral to appropriate specialists was recommended for further evaluation and longitudinal management. This case highlights the importance of maintaining a broad differential diagnosis when evaluating refra

Waldenström macroglobulinemia (WM) is an indolent mature B-cell lymphoproliferative disorder defined by bone marrow infiltration by lymphoplasmacytic lymphoma (LPL) and an associated serum monoclonal immunoglobulin M (IgM) gammopathy. In this case report, we describe a patient presenting with two serious and rare IgM-mediated complications of WM that require urgent treatment: secondary cold agglutinin syndrome and hyperviscosity syndrome. With prompt diagnosis and therapeutic plasma exchange, the patient's IgM-mediated complications improved, with a marked reduction in serum IgM and resolution of hyperviscosity-related symptoms. This highlights the importance of recognizing the possible complications of an otherwise indolent disease.