Congenital Cervical Vertebral Segmentation Failure Presenting as Refractory Torticollis in Infancy: A Case of Klippel-Feil Syndrome - Cureus

Background: Timely reperfusion remains the cornerstone of management in ST-segment elevation myocardial infarction (STEMI). However, a substantial proportion of patients continue to present beyond the recommended reperfusion window, particularly in low- and middle-income countries. The outcomes associated with delayed coronary revascularization in these late presenters remain incompletely defined. This retrospective observational study aimed to compare one-year mortality and left ventricular ejection fraction (LVEF) changes according to treatment strategy among STEMI patients presenting more than 12 hours after symptom onset. Methods: We conducted a retrospective observational cohort study including consecutive patients admitted with STEMI more than 12 hours after symptom onset between January 2020 and December 2025 at Mohammed VI University Hospital, Marrakech, Morocco. Patients were stratified according to treatment strategy into delayed percutaneous coronary intervention (PCI), conservative medical management, and coronary artery bypass grafting (CABG). The primary endpoint was one-year all-cause mortality, and the secondary outcome was change in LVEF. Mortality comparisons were

We’re sharing this article early to provide faster access to peer-reviewed, accepted research. It is citable and carries a permanent DOI. This version is subject to further edits and will be replaced automatically by the final Version of Record. All legal disclaimers apply. AbstractLiver tumors are life-threatening diseases that occur due to the rapid growth of liver cells and even result in a chronic condition. Nevertheless, conventional liver tumor detection struggled with the limitations of poor robustness, difficulties in identifying the complex boundaries, and inconsistent segmentation. Hence, the research introduced a hybrid dual attention-based pyramidal deep convolutional network and deep belief network (HDPCBN) for accurate liver tumor detection. Significantly, the HDPCBN approach deployed a pyramidal architecture to learn deep hierarchical features and intricate patterns of the tumor effectively. Moreover, the integration of the dual attention technique gathers the long-range relationships of both spatial and channel dimensions for accurate liver tumor detection.

The ASCO Quality Care Symposium 2026 (ASCOQLTY26) brought together oncologists, researchers, healthcare professionals, and patient advocates to discuss advances in cancer care quality, patient safety, and healthcare delivery. The meeting focused on improving patient outcomes, addressing disparities in cancer care, and sharing research aimed at strengthening oncology practice. Held on October 16–17, 2026, at the Hynes Convention Center in Boston, Massachusetts, and online, the symposium featured discussions on improving cancer care delivery, advancing patient-centered approaches, and ensuring equitable access to high-quality oncology services.

In pooled phase 3 data, mepolizumab lowered mean yearly systemic corticosteroid exposure by 178.97 mg in patients with a BEC of ≥150 cells/µL. Mepolizumab (Nucala) reduced total yearly systemic corticosteroid (SCS) exposure, particularly high-dose courses, in patients with COPD and type 2 inflammation receiving inhaled triple therapy, according to pooled phase 3 data presented at the American College of Chest Physicians (CHEST) 2026 Annual Meeting in Phoenix.¹,²Although treatment guidelines recommend SCS for COPD exacerbations, these agents are associated with complications in this population, prompting interest in targeted therapies capable of limiting their use.¹ Mepolizumab, a humanized monoclonal antibody targeting interleukin-5 (IL-5), is approved for patients with COPD and an eosinophilic phenotype.

Losing your train of thought or searching for a familiar word can raise some serious concerns for women approaching menopause. Researchers at Toronto Metropolitan University are working on investigating how this transition affects memory and how these changes impact brain health later in life. On this Menopause Day, Natasha Rajah, a professor of Psychology and Tier 1 Canada Research Chair in Sex, Gender and Diversity in Brain Health, Memory and Aging at TMU, is highlighting the research examining menopause and memory related issues showing signs of early dementia.

Waldenström macroglobulinemia (WM) is an indolent mature B-cell lymphoproliferative disorder defined by bone marrow infiltration by lymphoplasmacytic lymphoma (LPL) and an associated serum monoclonal immunoglobulin M (IgM) gammopathy. In this case report, we describe a patient presenting with two serious and rare IgM-mediated complications of WM that require urgent treatment: secondary cold agglutinin syndrome and hyperviscosity syndrome. With prompt diagnosis and therapeutic plasma exchange, the patient's IgM-mediated complications improved, with a marked reduction in serum IgM and resolution of hyperviscosity-related symptoms. This highlights the importance of recognizing the possible complications of an otherwise indolent disease.