Paxlovid for B.C. residents - Government of British Columbia

An immune checkpoint inhibitor–based multimodal downstaging strategy before liver transplantation was associated with improved posttransplant survival and a lower risk of recurrence among patients with hepatocellular carcinoma initially beyond the Milan criteria (single lesion not larger than 5 cm or two or three lesions not larger than 3 cm each), based on findings from a Chinese study published in JAMA Oncology. However, according to Ong et al, the strategy was also associated with a higher rate of acute rejection within 90 days posttransplantation. “By characterizing this post–liver transplantation benefit-risk profile, this multicenter matched cohort study may inform future prospective studies of immune checkpoint inhibitor–based pretransplant strategies in liver transplantation candidates and help clinical decision-making,” the investigators wrote.

Can changing your posture change your mood? Previous studies have suggested that body posture and movement can influence emotions. KAIST researchers have extended this line of research by showing that, when people perform the same "depressed" body movements, their brain responses differ depending on the level of their depressive symptoms. The findings are expected to provide a basis for research on which movements or exercises help which people, and on mental health care methods suited to each individual's condition. KAIST (President Choongsik Bae) announced on October 19 that a research team led by Professor Young-Gyun Park from the Department of Bio and Brain Engineering used a wireless brain imaging device to measure brain activity while people moved their bodies and identified differences in brain responses according to the level of depressive symptoms. When people feel sad or exhausted, they may hug their knees, sigh deeply, or let their shoulders droop. These movements express emotions. However, body posture can also influence emotions.

A protein called Miro1 found at elevated levels in the skeletal muscle of people with Type 2 diabetes may contribute to insulin resistance, potentially making it a target for future treatments that help the body regulate blood sugar, according to a study published today in Nature Communications. Researchers found that removing Miro1 restored the muscles' response to insulin in preclinical models, while exercise reduced the protein's levels in people with Type 2 diabetes. The study was led by senior author Dr. John P. Kirwan, recently named executive director of the OU Health Harold Hamm Diabetes Center at the University of Oklahoma. He conducted the research while at LSU's Pennington Biomedical Research Center and now brings his internationally recognized translational research program to OU, where he will build on his work to advance the understanding and treatment of diabetes. The study's first author is Elizabeth Heintz, a doctoral candidate who worked in the Integrated Physiology and Molecular Medicine Laboratory at Pennington Biomedical, and the co-corresponding author is Christopher Axelrod, who has since joined Kirwan at the Harold Hamm Diabetes Center.

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