“No Man Left Behind”: American Technology Ships with Our Values - Andreessen Horowitz

Only about 10 of the 2,000 types of apples growing in Austria can be found in supermarkets among the polished, pristine fruit usually on display – a sad ratio according to fans of historic varieties being primed for a comeback. One of the country’s biggest retail chains has embarked on a pilot rollout of unusual and long-forgotten apples enjoyed in previous centuries, riding an international trend of reviving heirloom fruit and vegetables. The Spar group is working with produce distributor Frutura to return two rare varieties to shops: Ilzer Rosenapfel (Ilzer Rose apple), dating from about 1840 from the southern state of Styria, and Falchs Gulderling, identified in the 1870s in South Tirol. “Farming never stands still,” said Frutura co-managing director Katrin Hohensinner-Häupl, calling it a dance between knowledge passed down through generations and innovation. Rediscovering antique apples using modern cultivation methods are “bringing their history and flavour back to life,” she said.

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Combination strategies enable simultaneous activation and silencing of key target genes to correct molecular pathways in pancreatic cancer. For the first time, scientists have designed combination therapies of small nucleic acid therapeutics based on the specific molecular characteristics of a tumor. These novel therapies work in an opposite but complementary way to regulate gene expression. This innovative approach, tested in pre-clinical models of pancreatic ductal adenocarcinoma (PDAC), shows superior anti-cancer effects compared to single nucleic acid therapies, offering the potential of flexible, precise, and personalized cancer treatments.