Neurokinin-3 receptor antagonists for vasomotor symptoms in menopause and breast cancer survivorship - CMAJ | Journal

Neurokinin receptor (NKR) antagonists are already widely used for treating menopausal hot flashes, representing a highly effective nonhormone treatment. A new study suggests they may also help breast cancer patients by limiting the spread of cancer cells and helping to prevent a recurring cancer diagnosis. Results of the study will be presented at the 2026 Annual Meeting of The Menopause Society in San Diego October 20-24, 2026. During menopause, declining estrogen levels disrupt the brain's thermostat located in the hypothalamus. This estrogen drop causes a specific group of brain cells, known as KNDy neurons, to become hyperactive and overproduce a peptide called neurokinin B (NKB). Overactive NKB signaling tricks the body into feeling overheated, triggering sudden sweating and flushing. Neurokinin receptor antagonists work by blocking these receptors, calming the overstimulated pathway and stabilizing body temperature regulation without using hormones.