Heart tests suggest astronauts could tolerate Mars' gravity after months in space - Medical Xpress
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A trip to Mars may be more feasible than previously thought, suggests a new study led by Northwestern Medicine, UT Southwestern and UT Houston that tracked the heart function of 13 astronauts during roughly six-month missions aboard the International Space Station.
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We’re sharing this article early to provide faster access to peer-reviewed, accepted research. It is citable and carries a permanent DOI. This version is subject to further edits and will be replaced automatically by the final Version of Record. All legal disclaimers apply. AbstractConventional cholesterol liposomes have poor stability, rapid clearance, and toxicity. This study used Rg3 to replace cholesterol for constructing curcumin-loaded liposomes (PCRL) and evaluated their potential for enhanced hepatocellular carcinoma therapy. Curcumin-loaded liposomes were prepared with Rg3 (PCRL) and cholesterol (PCCL) via thin-film hydration. Physicochemical properties, protein corona, in vitro behavior, in vivo tumor targeting, antitumor efficacy, and biosafety were assessed in H22 tumor-bearing mice. PCRL exhibited smaller particle size, superior storage/plasma stability, and comparable membrane packing to PCCL. Protein corona analysis showed reduced adsorption of immunoglobulin-like and complement proteins, prolonging blood circulation > 24 h and enhancing tumor accumulation.
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