Global health benefits and cost-effectiveness of indoor air purification to mitigate PM - Nature

Smoking during pregnancy is associated with adverse maternal, fetal, and neonatal outcomes. Although behavioral counseling remains first-line treatment, pharmacotherapy may be considered when counseling alone is insufficient. This scoping review mapped the available evidence on the safety and effectiveness of bupropion for smoking cessation during pregnancy. The review was conducted according to Joanna Briggs Institute methodology and reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR). MEDLINE (PubMed), Embase, the Cochrane Library, PsycINFO, and ClinicalTrials.gov were searched without date restrictions for English-language studies evaluating bupropion for smoking cessation during pregnancy. Two reviewers independently screened records, and the review team extracted data on smoking cessation, maternal safety, and fetal or neonatal outcomes. Of 599 records identified, 13 sources of evidence met the inclusion criteria. Maternal and fetal safety findings were generally reassuring, with no consistent increase in maternal adverse events, major congenital malformations, preterm birth, impaired fet

IntroductionHow does the gut microbiome change as we age? The link between gut microbiome changes and inflammationGut microbiome and age-related health conditionsCan the gut microbiome be targeted to promote longevity? From microbial shifts in later life to the distinctive gut communities of centenarians, researchers are investigating what the intestinal microbes reveal about how people age.