Gene syntax defines supercoiling-mediated transcriptional feedback - Science | AAAS

Sereda and colleagues show that chaperone-mediated autophagy declines with aging, which leads to enhanced senescent cell burden that is driven, in part, by failed macrophage-mediated immunosurveillance that can promote tissue dysfunction and systemic aging. This is a preview of subscription content, access via your institution

Data availabilityThe raw magnetic resonance imaging and iEEG data that contain patients’ personal information are protected and have restricted access for ethical and privacy reasons. Access can be obtained from the corresponding author upon reasonable request. Preprocessed data used to generate the figures and perform statistical tests are available in the following repository: https://osf.io/gy829. Code availability Analysis codes are available in the following repository: https://osf.io/gy829.

How Insertion Sequence-Mediated Gene Amplification Helps Acinetobacter baumannii Adapt to the Host KNOXVILLE, TN, October 18, 2026 /24-7PressRelease/ -- Acinetobacter baumannii is a major nosocomial pathogen with a remarkable capacity to adapt to both hospital and host environments. In this study, the researchers identified ISAba1-mediated amplification of the crp-osmC gene cluster as a previously unrecognized mechanism promoting host-associated fitness. Increased crp-osmC copy number enhanced bacterial growth, competitive fitness, serum survival, and colonization in mouse models. Transcriptomic analyses further linked this amplification to changes in metabolic flexibility and nutrient acquisition. Interestingly, the fitness advantage was accompanied by reduced biofilm formation and increased susceptibility to several antibiotics, revealing a potential evolutionary trade-off between host adaptation and antibiotic resistance in A. baumannii. This study was led by Yuqin Song and Jie Feng from the Institute of Microbiology, Chinese Academy of Sciences.

Environmental Surfaces and Interfaces provides a platform for disseminating original and world-leading scientific research in the field. There is an emphasis on surface/interface science, including gas-liquid, liquid-liquid, gas-solid, liquid-solid, solid-solid and bio-interface. We welcome studies that advance basic theory, instrument and methodology development, and lab and field experimental research on environmental surfaces and interfaces. This article collection features papers published in Environmental Surfaces and Interfaces since 2025 on the theme of materials-driven environmental pollutant removal. It focuses on the development of novel materials and their practical applications in environmental pollutant remediation. All articles are freely available for reading.