From mines to meadows: how science is reviving Europe’s forgotten landscapes - projects.research-and-innovation.ec.europa.eu

Data availabilityThe generated data are available in the Genome Sequence Archive (GSA)95,96 with accession number HRA009530 for human data (https://ngdc.cncb.ac.cn/gsa-human) and CRA020902 for mouse data(https://ngdc.cncb.ac.cn/gsa). The processed data are available in OMIX, China National Center for Bioinformation/Beijing Institute of Genomics, Chinese Academy of Sciences (https://ngdc.cncb.ac.cn/omix, accession number OMIX008107). Source data are provided with this paper. Code availabilityAll data were analyzed using published pipelines with parameters described in the Methods. ReferencesKim, J. J. & Kingston, R. E. Context-specific Polycomb mechanisms in development. Nat. Rev. Genet. 23, 680–695 (2022). Article Margueron, R. & Reinberg, D. The Polycomb complex PRC2 and its mark in life. Nature 469, 343–349 (2011). Article

Scientists have long been interested in cellular nanodiscs, tiny particles made from natural cell membranes that mimic many of the functions of living cells. While previous studies demonstrated the therapeutic potential of nanodiscs for drug delivery, detoxification and vaccines, one fundamental question remained unanswered: How does size influence how well they work?