Dynamic breaking of mirror symmetry in spin-dependent electron transport through chiral media causes enantiomeric excesses - Science | AAAS

Conceptual illustration linking SU(3)-inspired vacuum geometry with coherent and dissipative brain activity. Credit: Ahmed Farag Ali, Nader Inan, Ruben Laukkonen and Pavlo Mikheenko. AI-generated illustration created with OpenAI's ChatGPT. You bring your attention back to the breath. Sometimes, after many such returns, the effort eases. Thoughts lose their urgency, while awareness remains clear. Less occupies the mind, yet the moment still feels whole. We are interested in what makes that wholeness possible. Even an ordinary moment brings together vision, memory, bodily sensation and attention. Their contents change constantly, but they belong to one experience.

We’re sharing this article early to provide faster access to peer-reviewed, accepted research. It is citable and carries a permanent DOI. This version is subject to further edits and will be replaced automatically by the final Version of Record. All legal disclaimers apply. AbstractAlthough α-tocopherol (α-Toc) suppresses lipid oxidation overall, during linoleic acid oxidation it can paradoxically facilitate the formation of a unique hydroperoxide isomer bearing a hydroperoxyl group at the C11-position. Whether this isomer occurs in real foods and what it signifies in food oxidation and quality have remained unknown. Here, we initially applied a newly developed isomer-selective liquid chromatography–tandem mass spectrometry method to intact triacylglycerol autoxidized in the presence of α-Toc and identified the isomer within the triacylglycerol molecule. Interestingly, its formation coincided with the emergence of the pro-oxidant properties of excess α-Toc, pointing to its potential as an indicator of pro-oxidative conditions.

We’re sharing this article early to provide faster access to peer-reviewed, accepted research. It is citable and carries a permanent DOI. This version is subject to further edits and will be replaced automatically by the final Version of Record. All legal disclaimers apply. AbstractCryptococcus neoformans and Cryptococcus gattii are fungal pathogens that cause life-threatening infections, including cryptococcal meningitis. A distinctive feature of the cryptococcal cell wall is the extensive deacetylation of chitin to chitosan, a modification that is essential for virulence but whose structural role in cell-wall organization remains poorly understood. Here, we analyze the cell walls of wild-type strains of both species and their avirulent chitosan-deficient mutants, which serve as vaccine candidates. Loss of chitosan disrupted cell morphology and altered cell-wall ultrastructure, with more pronounced defects in C. neoformans. Solid-state NMR reveals that aggregated α-(1→3)-glucans form the principal rigid domain of the cell wall in both species and are closely associated with chitin microfibrils, whereas surrounding β-glucans and mannoproteins constitute a more dynamic matrix.

People's bodies may reflect their ages very differently at the molecular level, even when they are the same chronological age, according to a new study.