Cooling water to near freezing breaks the activity–stability trade-off of water oxidation electrocatalysis - Nature

Chimeric RNAs (chRNAs) expand transcriptomic and proteomic diversity by joining sequences from distinct genomic loci, yet their physiological functions remain poorly understood. In a recent paper published in Nature, Venezia et al. show that inflammation induces CTCF-dependent chRNA formation in mammalian immune cells and that a Gsdmd-Tmem106a chRNA encodes a functional fusion protein that modulates pyroptosis and the balance between antibacterial defense and inflammatory pathology. The mammalian genome contains a surprisingly limited number of protein-coding genes relative to the complexity of mammalian organisms. Alternative splicing, RNA editing, non-canonical translation and post-translational modification expand the functional output of this finite genome. Chimeric RNAs (chRNAs), in which sequences from distinct genomic loci are joined within a single transcript, may represent another layer of this regulatory complexity.1,2,3 Historically, chimeric transcripts have been closely associated with cancer-associated chromosomal rearrangements.

ORCID: orcid.org/0009-0004-7198-86071, Nisarg A. Shah2 na1, Mingze Xia2 na1, Mike Peven2 na1, Nanthini Narayanan3, Rishabh Nanawati2, Nuren Zhaksylyk2 na1, Ibrahim Abboud1 na1, Ayesha Javaid1 na1, Vishal M. Patel2,4, S. Swaroop Vedula3 & … Shameema Sikder1,3 We’re sharing this article early to provide faster access to peer-reviewed, accepted research. It is citable and carries a permanent DOI. This version is subject to further edits and will be replaced automatically by the final Version of Record. All legal disclaimers apply.