Chromosome Anchors Turn Spherical Before Cell Division - Mirage News
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Osaka, Japan – Whenever a cell divides, it has to split its chromosomes perfectly between two daughter cells, and even a single mistake can be disastrous. Now, researchers from Japan have found that one of the key structures that makes this possible takes a surprising shape: a hollow sphere. In a study to be published in Science Advances, researchers from the University of Osaka and their collaborators have revealed how a protein complex called the constitutive centromere-associated network (CCAN) assembles inside the cell, forming a spherical shell-like structure within the nucleus. CCAN sits at the centromere, the pinched 'waist' of each chromosome, where it forms the basis of a larger structure called the kinetochore. The kinetochore acts like a tow hitch - it links each chromosome to the cellular ropes that pull chromosomes apart during cell division. Although previous studies have revealed a single CCAN unit's structure in fine detail, each kinetochore contains dozens of these units, and consequently how they are arranged together inside cells has remained a mystery.
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