25 Years of Scientific Discovery Aboard the International Space Station - NASA (.gov)

We’re sharing this article early to provide faster access to peer-reviewed, accepted research. It is citable and carries a permanent DOI. This version is subject to further edits and will be replaced automatically by the final Version of Record. All legal disclaimers apply. AbstractConventional cholesterol liposomes have poor stability, rapid clearance, and toxicity. This study used Rg3 to replace cholesterol for constructing curcumin-loaded liposomes (PCRL) and evaluated their potential for enhanced hepatocellular carcinoma therapy. Curcumin-loaded liposomes were prepared with Rg3 (PCRL) and cholesterol (PCCL) via thin-film hydration. Physicochemical properties, protein corona, in vitro behavior, in vivo tumor targeting, antitumor efficacy, and biosafety were assessed in H22 tumor-bearing mice. PCRL exhibited smaller particle size, superior storage/plasma stability, and comparable membrane packing to PCCL. Protein corona analysis showed reduced adsorption of immunoglobulin-like and complement proteins, prolonging blood circulation > 24 h and enhancing tumor accumulation.

We’re sharing this article early to provide faster access to peer-reviewed, accepted research. It is citable and carries a permanent DOI. This version is subject to further edits and will be replaced automatically by the final Version of Record. All legal disclaimers apply. AbstractPleural effusion is a common clinical finding with heterogeneous causes, including infection, malignancy, heart failure, tuberculosis, pulmonary embolism and systemic disease. Because patients often encounter pleural effusion as an imaging finding rather than as a diagnosis, short-video platforms may shape early understanding, anxiety and care-seeking behaviour. Evidence on the quality of this content is lacking. We conducted a cross-sectional content analysis of publicly available pleural effusion–related short videos on Douyin and Bilibili. The Mandarin search term “胸腔积液” (pleural effusion) was entered on 15 May 2026 and the first 150 results returned under each platform’s default ranking were screened.

A diorama of some of the earliest animals on Earth. Image via Wiki Commons. An ancient fossil bed in Mongolia preserves tiny organisms in remarkable detail. Some even have structures resembling embryos. But there’s something conspicuously missing: animals.