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The investigational factor XI (FXI) monoclonal antibodies amrecibart and cenvacibart demonstrated successful anticoagulation with a favorable safety profile in preclinical and phase 1 clinical studies, representing a novel treatment strategy for patients with thrombosis. The results were published in Blood by Dan Chalothorn, PhD, of Regeneron Pharmaceuticals, and colleagues. The research team first compared the mechanisms and coagulation effects of amrecibart and cenvacibart with other FXI-targeted monoclonal antibodies in both human and nonhuman primate plasma using an in vitro functional clotting assay.1Targeting the Intrinsic PathwayWith unique FXI/FXIa-binding mechanisms, amrecibart and cenvacibart address an unmet need for novel treatments with a favorable risk-benefit profile because current standard-of-care anticoagulants carry a high risk for bleeding. Cenvacibart and amrecibart block FXI activity by targeting the catalytic domain and the apple 2 domain of FXI/FXIa, respectively. Although standard-of-care anticoagulants target the extrinsic coagulation pathway, these monoclonal antibodies specifically target the intrinsic coagulation pathway.

Google is making the Gemini AI assistant that’s already in millions of cars, trucks, and SUVs a lot more personal — a move that could push consumers even deeper into the company’s ecosystem of products. The company said Tuesday it’s upgrading Gemini in vehicles with a personal intelligence feature that can draw on information from Gmail, Google Calendar, YouTube, Maps, Google Search history, and other connected Google services to understand your preferences, activities, and past experiences.

Some iPhone Duo buyers who were told they’d have to wait until 2027 may be getting their phones much sooner. Pre-orders for the Duo opened Friday, Oct. 16, and sold out almost immediately. Delivery estimates quickly slipped into late January 2027. Over the weekend, though, a number of customers began reporting that Apple had moved their delivery dates up, in some cases to the phone’s Friday, Oct. 23 launch. Given the rush on the Duo, Apple has capped purchases at two per order. According to a post from TechDroider on X, the company is also canceling suspicious orders to curb reselling. Apple hasn’t confirmed the cancellations.

Ars Technica is here to help with a guide to the medium-lift space race. Nova rocket's upper stage, flight article, during a fit test.