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Tiny Genetic Tweak From An Ancient Virus Might've Prevented Chimpanzees From Developing Brains Like Ours - ScienceAlert

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Young chimpanzees enjoy some fruit. (Martin Harvey/The Image Bank RF/Getty Images)

Humans and chimpanzees are remarkably similar, despite the major differences in how our societies have panned out. After about 5-6 million years of evolution from a common ancestor, only 1.2 percent of our DNA is different. A virus that infected chimpanzees (Pan troglodytes) – but not humans – about 4 million years ago is partly responsible. This ancient retrovirus made a tiny tweak to chimp DNA that has led to some major differences in how our brains develop, according to a new study published in Science Advances today. "We wanted to understand how human and chimpanzee brains could have evolved differently when so many of their protein-making genes are similar," lead author Patricia Gerdes told ScienceAlert. Gerdes is a molecular neurogeneticist at Lund University in Sweden. "We knew that ancient viruses can leave DNA behind in the genome, and those remnants can affect nearby genes," she said. "PTERV1 (Pan troglodytes endogenous retrovirus-1) was a particularly interesting candidate because it is found in chimpanzees and other African apes but not in humans.

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