Targeted pathway mining reveals novel modified hexapeptides from the demiguisin family - Nature
IntroductionBirds rely on a collection of behavioural, physiological, and chemical defences to mitigate the constant threat posed by pathogens and parasites in their environment1. Preen oil from the uropygial gland (UG) is a key component of avian integumentary immunity, supporting feather maintenance and waterproofing, while the UG is also known to harbour diverse microbes, including γ- and α-Pseudomonadota and Actinomycetota, that contribute to feather defense2,3. We recently exemplified a case of the bacterial isolate Amycolatopsis sp. PS_44_ISF1 derived from the UG of the toxic bird Pachycephala schlegelii that can directly contribute to the bird’s chemical defence system, by producing bioactive metabolites such as the antifungal macrolactam ciromicin A3,4, the co-secreted tensioactive lipopeptide family pachycephalamides, and a highly modified hexapeptide, named demiguisin A (1) (Fig. 1). The chemical structure of 1, caught our interest, as it contains non-proteinogenic piperazic acid (hexahydropyridazine-3-carboxylic acid, Piz) residues within the sequence Gly–β,γ-OH-Piz–Leu–Piz–DHPA–γ-c-Pro (Fig. 1)3,5.
This article is an excerpt. To read the full content, visit the original source. Nature
Related articles
Scientists Discover a Hidden Hydrogen Pathway That Could Transform CO2 Into Valuable Fuel - SciTechDaily
Surface of a copper catalyst depicting CO2 hydrogenation to methanol. Credit: Shivam ChaturvedicScientists have uncovered an unexpected pathway for hydrogen transfer during catalytic CO2 conversion. A computer model designed to predict how carbon dioxide becomes useful chemicals produced a surprising error: It identified formic acid as the main product instead of methanol. When scientists expanded the model to account for thousands of previously overlooked reactions, its predictions changed dramatically and aligned much more closely with experimental results. Researchers at the Indian Institute of Science (IISc) developed a computational framework that maps 9,389 chemical reactions involved in converting CO2 into fuels and chemicals on a copper catalyst. Compared with a smaller model containing just 152 reactions, the expanded network predicted approximately 40 times more CO2 conversion and correctly identified methanol and carbon monoxide as major products. The research was published in Nature Communications.
Experimental characterization and scaling of flexural rigidity in sewn multilayer structures - Nature
We’re sharing this article early to provide faster access to peer-reviewed, accepted research. It is citable and carries a permanent DOI. This version is subject to further edits and will be replaced automatically by the final Version of Record. All legal disclaimers apply. AbstractSewing is one of the established methods used to fabricate and assemble multilayer insulation (MLI) blankets for aerospace applications, yet the resulting effective flexural behavior remains insufficiently understood. This study investigates the room-temperature, quasi-static flexural behavior of MLI blankets composed of aluminized BoPET radiation shields and polyester net spacers across structural configurations of 2, 6, 12, and 24 layers. A full factorial design was employed to evaluate the influence of the number of layers, stitch density, needle thread tension, and needle foot force. Statistical analyses demonstrated that the number of layers is the dominant factor governing flexural response. Among the sewing parameters, needle thread tension was associated with modifications in bending length, while needle foot force primarily affected local compaction.
Salt crystals could hold clues to life beneath Enceladus's ice - Phys.org
The ocean beneath Saturn's moon Enceladus lies under kilometers of ice, but some of its contents do reach the surface. Jets near the south pole spray out water vapor and icy particles, offering a way to investigate the hidden ocean without drilling down to it.
Adma and Ackr3a regulate cardiac lymphatic vessel formation and function during heart development and regeneration - Nature
AcknowledgementsWe thank the Saban SC2 core for the 10X single nuclei Multiome analysis and Cellular Imaging core. We also thank Dr. Stanislao Travisano, Dr. Sunhye Lee, Dr. David Wong and Dr. David Cobrinik for helpful discussion and suggestions, and Ms. Kimberly Luna and Dr. Michael Harrison for technical support. We acknowledge the support of The Saban Research Institute at CHLA and its Core Pilot Program for the use of the Spatial Biology & Genomics Core. FundingThis study is supported by fellowship from CIRM Scholar Award (EDUC4-18082) (XF) and The Heart Ambassadors Intramural Grant (XF), NIH (NHLBI) grant 1R01HL148706 (CL), Alfred E. Mann Cell and Gene Therapy Research Fund (CL), Saban Core Pilot Award, Saban Intramural 2nd R01 award (CL) and R35HL150713 (KDP). Author informationAuthor notesThese authors contributed equally: Hui-Yu Chen, Yuhan Sun.
0 comments
No comments yet. Be the first to share your thoughts!