Spatio-Temporal Geographic Networks for Value Co-Creation and Technology Transfer in China with Patent Data - Nature

Lorlatinib continues to deliver exceptional long-term disease control in previously untreated ALK-positive advanced non-small cell lung cancer, but new translational data from CROWN are beginning to clarify why a minority of patients still progress early. At ESMO Congress 2026, an exploratory circulating tumor DNA analysis from the phase III CROWN trial showed that early progression on lorlatinib was associated with greater baseline genomic complexity, higher blood-based tumor mutational burden, more frequent TP53 alterations, and enrichment of inflammatory-response pathways.

Frutiger Aero design combines old-school tech with green and blue natural imagery. Looking at 22-year-old Sammy Conti's room is like looking into a fishbowl. Shades of blue fill the space, interspersed with neon green and the occasional pop of orange or yellow. Vines, bubbles, and jellyfish hang from the ceiling. Moving lamps are everywhere: lava lamps, bubble lamps, aquarium lamps with roving tropical fish. Then there are objects that feel out of place: a purple Game Boy Advance, Nintendo 64 cartridges, Wii and PlayStation game cases hung like art on a gallery wall, and a DIY mirror in the shape of an old Microsoft Windows logo. The confluence of nature and old-school tech isn't random. It's Frutiger Aero, an aesthetic inspired by the early internet, embraced by Gen Zers who say it represents a future that was promised but never arrived — one where technology is a source of inspiration and fuel for creativity, coexisting with nature and helping us ascend to our highest selves. "You grow up thinking the world is going to be this green utopia where we coexist with nature and have technology and it helps us," Conti told Business Insider.

In our world of rising tech prices, when a new device hits the scene, the ultimate question is: is it worth it? If you're going to spend your money, you want it to be the best of the best. But the so-called best really depends on your priorities — do you want something that's the best value, best performance, or has the best features? As someone who spends nearly every day writing about e-readers, Boox devices have shaken things up. These E Ink tablets challenge what we previously thought an e-reader could be, with added features you won't find on a Kindle or Kobo. But are they worth it? Well, that depends on what you're looking for. Boox pricing: Is it more expensive than a Kindle? First things first, let's talk price. Boox e-readers are really E Ink tablets, which means they can do a lot more than Kindle or Kobo e-readers. But does that affect their price? Less so than you'd think. Especially with tech prices on the rise, e-reader prices have been evening out across the board. Generally, Boox e-readers are more expensive than both Kindle and Kobo devices, but not by much. The best way to compare prices is to look at each brand's 6-inch e-reader prices.

Garmin watches are some of the best fitness trackers you can get, but they aren't exactly cheap—some cost over $1,000. Thankfully, with some patience and brand know-how, you can actually get a great Garmin watch for less than $200. Right now, some of my favorite entry-level models, including the Garmin Vivoactive 5 and Garmin Forerunner 165, are over 20 percent off. If you've been thinking about trying out Garmin, now is a good time to buy. For more wearable recommendations, check out our guides to the Best Garmin Watches, Best Smartwatches, Best Smart Rings, and Best Sleep Trackers. Love WIRED? Add us as a preferred source on Google to see more of us. Garmin Vivoactive 5 for $198 ($102 Off)Courtesy of GarminGarminVivoactive 5The Vivoactive 5 is a great first Garmin watch, and it's 34 percent off right now. It's an older model (it launched in 2023), but you still have many of the brand's best fitness and health features available, including in-depth fitness metrics, Body Battery (basically your energy score throughout the day), sleep coaching, and stress tracking. It's also small, lightweight, and a little sleeker than some of the brand's more outdoor-centric watches.