Research on concrete structure damage detection based on piezoelectric sensing technology and morphological fractal method - Nature

IntroductionPhenotypic profiling and cellular assays play important roles in early drug discovery, offering valuable insights that have helped uncover new disease mechanisms1,2. One approach is morphological profiling, where a large number of quantitative metrics (features) – such as cell size, shape, and texture – can be extracted from individual cells within images, creating a unique fingerprint for every given condition3,4. This shift towards large-scale morphological profiling or phenomics allows for the exploration of less-characterized phenotypes, thereby facilitating the discovery of novel disease biomarkers5,6,7. Cell Painting is a widely adopted standardized assay for morphological profiling of 2D monolayer cell cultures. By staining distinct cellular compartments and imaging in multiple channels, it enables the extraction of vast amounts of phenotypic information. This unbiased approach is powerful for predicting mechanisms of action8,9, identifying off-target effects10, and detecting phenotypes of environmental toxicants11,12.

If you like playing daily word games like Wordle, then Hurdle is a great game to add to your routine. There are five rounds to the game. The first round sees you trying to guess the word, with correct, misplaced, and incorrect letters shown in each guess. If you guess the correct answer, it'll take you to the next hurdle, providing the answer to the last hurdle as your first guess. This can give you several clues or none, depending on the words. For the final hurdle, every correct answer from previous hurdles is shown, with correct and misplaced letters clearly shown. An important note is that the number of times a letter is highlighted from previous guesses does necessarily indicate the number of times that letter appears in the final hurdle. Want more tech and digital culture news delivered to your inbox daily or sent straight to your device? Sign up for Mashable's Top Stories newsletter or get Mashable push alerts today. If you find yourself stuck at any step of today's Hurdle, don't worry! We have you covered.