Prevalence and severity of mental health problems in early-career researchers: a systematic review and meta-analysis - Nature

IntroductionHypertension is a major global health concern and a leading cause of morbidity and mortality [1]. It is estimated that more than 19 million annual deaths are attributed to cardiovascular disease (CVD) worldwide [2]. In Japan, high blood pressure (BP) has been consistently identified as a strong risk factor for the national burden of CVD, in terms of notable incidence, mortality, direct/indirect healthcare costs, and quality-adjusted life years (QALYs) associated with this condition [3, 4]. Although age-specific mean BP declined in Japan over recent decades [5], hypertension remains a critical public health issue, particularly because of the rapid aging population. The proportion of individuals aged ≥65 years is projected to reach approximately 35% by 2040 in Japan [6], highlighting a potentially higher future burden of hypertension in this country. While the prevalence of hypertension increases with age, population aging may offset the benefits of declining BP levels in each age group. As a result, the future burden of hypertension in Japan remains uncertain.

Persistent pain despite targeted therapy remains a major challenge in patients with rheumatoid arthritis (RA) and spondyloarthritis (SpA), and neuropathic pain-like features may contribute to this residual pain. We conducted a cross-sectional study including 155 patients receiving biologic or targeted synthetic disease-modifying antirheumatic drugs (bDMARDs or tsDMARDs; 78 RA and 77 SpA) to determine the prevalence of neuropathic pain-like features and identify associated clinical factors. Neuropathic pain-like features were screened using the Douleur Neuropathique 4 (DN4) and painDETECT questionnaires. Univariable logistic regression analyses were performed separately for each disease group, followed by parsimonious multivariable models including functional impairment, disease activity, and current pain intensity. Neuropathic pain-like features (DN4 ≥4) were identified in 19 (24.4%) patients with RA and 21 (27.3%) patients with SpA, with no statistically significant between-group difference (p = 0.679). Although median painDETECT scores were significantly higher in SpA, the distribution of painDETECT categories did not differ significantly between the two groups. In univariable an

Liberty Mutual’s Amy Gross discusses how AI, data analytics, drones, and connected technologies are helping construction firms identify risks earlier, improve safety and claims outcomes, and make better-informed decisions — while creating new demands around cybersecurity, privacy and human oversight. In August 2026, Risk & Insurance caught up with Amy Gross, General Manager, North America Construction, Global Risk Solutions, Liberty Mutual. What follows is a transcript of that discussion, edited for length and clarity.