Pink, pretty, and protective. A dumbo octopus is here with a message from the deep-sea. - Popular Science

We’re sharing this article early to provide faster access to peer-reviewed, accepted research. It is citable and carries a permanent DOI. This version is subject to further edits and will be replaced automatically by the final Version of Record. All legal disclaimers apply. AbstractColeoid cephalopods, squids, cuttlefish, and octopuses, have emerged as powerful model organisms for studying neurobiology, development, and behavior, however, cellular tools for investigating their specialized tissues remain limited. In particular, their venom producing gland, the posterior salivary gland (PSG), has been extensively described anatomically and histologically, yet remains largely inaccessible to experimental investigation at the cellular level. Here, we report the first establishment of primary cell cultures derived from both the optic lobe (OL) and PSG tissues of Octopus bimaculoides. Building on recent advances in cephalopod brain cultures, we adapted and optimized dissociation and culture conditions to support short-term survival and attachment of cells in vitro.

Octopuses, squid, and cuttlefish possess some of the most sophisticated nervous systems in the animal kingdom, giving them remarkable abilities such as solving problems and rapidly changing their appearance to blend into their surroundings. But how did these extraordinary capabilities evolve? Scientists have uncovered a surprising clue that may lie not in the genes themselves, but in the way DNA is folded and arranged inside cells. Researchers at the University of Vienna discovered that a massive reorganization of DNA hundreds of millions of years ago brought previously separated genetic regions into contact. These newly formed connections changed how genes could interact and be controlled, potentially helping drive the evolution of the unusually complex nervous systems found in these animals, which are collectively known as coleoid cephalopods.

Researchers co-led by Cedars-Sinai Health Sciences University have identified an enzyme that may help protect the liver from the damage that can occur as the most common form of liver disease becomes more severe. The findings, from a preclinical study published in Nature Metabolism, could eventually support new strategies for preventing serious liver injury and progression toward liver failure. An estimated 100 million people in the U. S. have metabolic dysfunction-associated steatotic liver disease (MASLD), formerly called nonalcoholic fatty liver disease, according to the American Liver Foundation. Roughly 20% to 25% of those affected go on to develop metabolic dysfunction-associated steatohepatitis (MASH), a more serious form of the condition in which excess liver fat is accompanied by inflammation, cell injury and scarring.