Scientists find breast cancer cells hiding behind protective “shields” - Science Daily

She’s bubblegum pink with a permanent little smile. She sports a pretty flower on her head sports a black tattoo on one of her eight arms. But don’t let this dumbo octopus’ adorable exterior fool you. Miss Abyss is here on serious business. “Miss Abyss is a dumbo octopus from the deep-sea, and she is on a journey all across the country looking for allies to support her to help defend the deep-sea,” Angelo Villagomez, a research fellow at the Center for American Progress (CAP), tells Popular Science.

Researchers co-led by Cedars-Sinai Health Sciences University have identified an enzyme that may help protect the liver from the damage that can occur as the most common form of liver disease becomes more severe. The findings, from a preclinical study published in Nature Metabolism, could eventually support new strategies for preventing serious liver injury and progression toward liver failure. An estimated 100 million people in the U. S. have metabolic dysfunction-associated steatotic liver disease (MASLD), formerly called nonalcoholic fatty liver disease, according to the American Liver Foundation. Roughly 20% to 25% of those affected go on to develop metabolic dysfunction-associated steatohepatitis (MASH), a more serious form of the condition in which excess liver fat is accompanied by inflammation, cell injury and scarring.

A small clinical trial led by researchers at Dana Farber Cancer Institute has tested a treatment strategy that began with laboratory discoveries at the Salk Institute. The idea is to activate the vitamin D receptor and, in doing so, alter the protective environment surrounding pancreatic tumors. That change could potentially make this notoriously difficult cancer more vulnerable to existing treatments. The study, published in Nature Cancer, included patients with previously untreated metastatic pancreatic cancer. Participants received standard chemotherapy either alone or in combination with paricalcitol, a vitamin D analog already approved by the FDA for other medical uses.