Pharmacotherapy for obesity management in adults: 2025 clinical practice guideline update - CMAJ | Journal

We’re sharing this article early to provide faster access to peer-reviewed, accepted research. It is citable and carries a permanent DOI. This version is subject to further edits and will be replaced automatically by the final Version of Record. All legal disclaimers apply. Observational evidence is increasingly central to prognostic precision in early intervention in mental health, particularly in Clinical High-Risk for Psychosis (CHR-P) populations where trajectories are heterogeneous and clinical decisions unfold sequentially. In this context, baseline pharmacological exposure should not be treated merely as a nuisance variable or dismissed because it may reflect confounding by indication, confounding by severity, or protopathic bias. These mechanisms limit causal interpretation, but they may also explain why treatment exposure carries prognostic information. Antipsychotic, antidepressant, benzodiazepine, or combined exposure at CHR-P inception may encode prior clinical deterioration, symptom burden, comorbidity, treatment-seeking pathways, clinician concern, partial treatment response, or pharmacologically attenuated expression of emerging psychosis.

Research Co. polling puts the Conservatives at 44% and the NDP at 40%, while David Eby and Lorne Doerkson are tied as preferred premier

Informations complètes et à jour, compilées par Google Actualités à partir de sources d'actualité du monde entier

CalgaryWith the Alberta referendum now in the books, some First Nation chiefs are calling on the provincial government to drop its appeal of a judge’s decision to quash the citizen petition on separation. Province says it won't be doing thatJennifer Keiller · CBC News · Posted: Oct 23, 2026 6:56 PM EDT | Last Updated: 7 hours agoListen to this articleEstimated 4 minutesThe audio version of this article is generated by AI-based technology. Mispronunciations can occur. We are working with our partners to continually review and improve the results. Chief Allan Adam speaks in March outside of the Alberta legislature, calling on the province to stomp out the citizen petition on separation. With the referendum now done, Adam says the province should drop its appeal of a ruling on the petition. (Jason Franson/The Canadian Press)With the Alberta referendum now in the books, some First Nation chiefs are calling on the provincial government to drop its appeal of a judge’s decision to quash the citizen petition on separation. “I mean, now that the referendum’s happened, the issue’s moot,” said Siksika Nation Chief Samuel Crowfoot.

White House lifts tariffs on some Canadian goods as midterm elections loom53 minutes agoNardine SaadGetty ImagesCanada and the US are currently locked in a tit-for-tat trade war The Trump administration is lifting some of its 50% tariffs on Canadian goods two weeks before the midterm elections, after a Republican candidate in a key Senate race said she had lobbied for the change. Starting on 30 October, tariffs will be eased on products including "plywood sheets, some paper products, certain machinery and refrigeration equipment," the White House said on Friday. Republican Senator Susan Collins, who is in a tight race to keep her seat in Maine, first announced the exemptions, saying they would help her state's agriculture industry. The US imposed a 50% levy on $20bn (£15bn) of Canadian goods after trade talks between the two countries collapsed in August. Getty ImagesMaine Senator Susan Collins is seeking to keep her seat in November's midterm electionsCanada has imposed a series of countermeasures against US tariffs, which Prime Minister Mark Carney said were "necessary to protect our workers".