Metabolon Launches AI-Enabled Splash & Ripple to Accelerate Metabolomics-Driven Drug Discovery - BioPharma APAC

We’re sharing this article early to provide faster access to peer-reviewed, accepted research. It is citable and carries a permanent DOI. This version is subject to further edits and will be replaced automatically by the final Version of Record. All legal disclaimers apply. AbstractInvasive fungal infections cause high mortality in immunocompromised patients, yet the spatially organized metabolic circuits that enable pathogens to evade host immunity remain poorly understood. Here we present an integrated computational–experimental framework coupling high-resolution spatial metabolomics with attention-enhanced deep learning to dissect immune evasion mechanisms within fungal infection microenvironments. We constructed a spatial metabolic atlas from MALDI-MSI and DESI-MSI data acquired on murine invasive pulmonary aspergillosis tissue sections, identifying 1,847 reproducible metabolite features across histologically distinct tissue compartments.

IntroductionAlthough clinical trials are widely regarded as the standard approach for determining treatment efficacy, they do not prioritize the vast heterogeneity of molecular phenotypes, disease mechanisms, and responses to treatments1,2. This heterogeneity can limit the generalizability of clinical trial outcomes, potentially resulting in suboptimal patient care3. Furthermore, pediatric populations face an additional challenge in that some treatment guidelines, such as those for septic shock or fluid resuscitation in trauma, are extrapolated from adult studies rather than derived from pediatric-specific research4,5,6. One solution to the challenges posed by heterogeneity is personalized medicine, an approach that tailors treatments and prevention strategies to each individual’s biology7. To transition from a population-based to a personalized approach, the research community has turned to omics technologies to provide comprehensive molecular datasets at various biological levels to achieve a deeper molecular understanding of disease heterogeneity, mechanisms, and other sources of variability8.

Apple isn't done with new product releases quite yet. Fall has proven to be quite a busy season for Apple, with the September iPhone event, which saw the grand debut of the new iPhone 18 Pro and iPhone Duo. Apple then followed up with the "Welcome Home" smart home launch event earlier this month, where the company unveiled its new HomeView device alongside a slew of other products. Apple is now preparing for an Oct. 28 event in Los Angeles. What does Apple have in store next? The invitations for the event went out with the tagline "Pro and Tell," so all signs point to a new MacBook Pro. In fact, we fully expect that Apple will reveal the long-awaited touchscreen OLED MacBook. However, we all know Apple loves a "One More Thing" approach, and we're following rumors on a few new devices. Here's everything we expect to learn at the "Pro and Tell" special event next week. Touchscreen OLED MacBook Pro

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Slightly lighter and slimmer than previous 6-inch Kindle Improved front lighting with nine LEDs instead of four