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‘It’s really the exception that it’s not MS.’ Why Christina Applegate’s misdiagnosis is quite rare.

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Source: The Boston Globe
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Applegate said that her symptoms first started in 2021 with numbness in her toes and pain up her legs. She was tested for “everything under the sun.” “Brain, spinal MRIs, spinal tap, nerve tests. I progressively got worse... Then there was the day the doctor showed me almost 40 lesions on my brain. That was my answer for everything that was going on.” Her doctor wanted to take Applegate off the regimen infusion to watch her B-cells and saw no change. That began a study into her diagnosis. “She came into my room and said, ‘Congratulations, you don’t have MS’,” a tearful Applegate told her co-host Jamie-Lynn Sigler, who has been public about her own battle with MS. “You don’t get misdiagnosed and all of a sudden you’re better... in some ways I’ve gotten worse,” she said. “It’s going to be an online investigation my doctors are going to be getting into: why did this happen? I have every symptom of someone with MS. There are many things that mirror MS.”Dr. Michael Levy, director of the Neuroimmunology Clinic and Research Laboratory at Mass General Brigham and an associate professor at Harvard Medical School, said that reversal would be unusual.

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