Interpreting Kidney Donor Pregnancy Signals, With Amit Garg, MD, PhD - HCPLive
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News|Videos|October 22, 2026 Chance, biology, and shared genetics may explain more small for gestational age births after living kidney donation. Small for gestational age births and shared donor-recipient genetics complicate the picture of pregnancy after living kidney donation. Investigators behind a new Canadian study of pregnancy after living kidney donation are weighing why donors had more small for gestational age (SGA) births than matched nondonors, and whether shared genetics with recipients could play a role.¹The matched cohort study, presented at American Society of Nephrology (ASN) Kidney Week 2026 by Amit X. Garg, MD, PhD, and published simultaneously in JAMA, spanned 3 provinces and also found a modest increase in hypertensive disorders of pregnancy among donors.¹ How Did the Study Compare Donors and Nondonors? Using linked administrative health databases from Ontario, British Columbia, and Alberta, investigators compared 385 pregnancies in 252 living kidney donors with 1,540 matched pregnancies in 1,535 nondonors.¹ To reflect donors’ healthier baseline profile, nondonors with any of 35 conditions that would preclude donation were excluded.
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