Injectable “satellite livers” could offer an alternative to liver transplantation - MIT News

Once an organ is removed from a donor’s body, the clock starts ticking. Surgeons usually flush the organ with a preservative solution, bag it, and put it on ice—where it immediately starts to degrade. The team has a matter of hours to get it into a recipient’s body. There’s another option—one that has been growing in popularity in recent years, especially for donated organs that aren’t in the healthiest state. Some hospitals opt to put them on machines that pump them with nutrients and remove waste products, usually for around six to 12 hours. It’s a bit like being back in a body. This allows doctors to assess the organs, and some recent studies suggest that time spent on these perfusion machines helps them do better once they’re transplanted. Now, scientists have found that perfused organs seem to get younger, at least at a molecular level. The research, shared with MIT Technology Review, provides molecular clues as to why organs from younger donors are known to have a higher success rate. It might also help explain why perfused organs are less likely to fail once they make it into a recipient. The researchers behind the study hope to find new ways to test the health of donated

LHSC heart transplant recipient, Raj Mittal is pictured with Cardiac Surgeon, Dr. Dave Nagpal. September 24, 2026In a transplant first for a Canadian recipient, the provincially shared Transmedics Organ Care System kept a donor heart beating outside of the body, helping to expand transplant possibilities for London Health Sciences Centre patient, Raj Mittal. The heart transplant team from London Health Sciences Centre (LHSC) completed a cardiac transplant using the Transmedics Organ Care System (OCS) organ care system, often referred to as a "heart in a box", to implant a donor heart that may otherwise may not have been available for transplant.  Taking place in February 2026, the milestone procedure was made possible through access to the provincially acquired TransMedics Organ Care System Heart technology, specialized team training, and years of collaboration with Ontario Health and Trillium Gift of Life Network. Unlike traditional cold storage that preserves an organ using ice in a standard cooler during transport from one hospital to another, heart in a box systems are used to revive a donor heart that has stopped beating after circulatory death.

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