In silico biological discovery with large perturbation models - Nature

Mitochondria are the tiny powerpacks that supply most of the energy our cells need. Their ability to generate this energy relies on a distinctive architecture: two membranes, one tucked inside the other, separated by a narrow gap called the intermembrane space (IMS). This tiny space helps sustain the chemistry of energy production, making its organization critical to how these cellular powerpacks function. Now, a new study led by a University of Ottawa Faculty of Medicine investigator reports a potentially transformative discovery: the volume of the IMS is genetically controlled and adjustable. By controlling where this space expands or narrows within each mitochondrion, cells can actively shape the internal architecture of their powerpacks and tune how they function.

Pandemics can arise wherever animal or human populations are sufficiently large, and they are not confined to the modern age. Johan Jakobsson, Professor of Molecular Neurogenetics at Lund University, believes that the findings from the new study are highly relevant: they show that a virus can cause a DNA sequence to change across an entire population. "The virus we investigated specifically affected chimpanzees. Yet humans and chimpanzees have largely the same genetic makeup. That is why it is important to understand the differences in how genes are regulated. Our findings suggest that one gene, LINC00662, plays a significant role in early human brain development," says Johan Jakobsson.

Graphical summary of the project's key results. Credit: Fernández B., Bustos M., Vera T., Palacios M., Hill D. & Astudillo D. Pollution from human-generated waste in marine ecosystems has reached critical levels, with cigarette butts (CBs) among the most persistent and harmful pollutants. Globally, an estimated 4.5 trillion cigarette butts are discarded annually, making them the most common type of litter on beaches over the past three decades.